20mg Retatrutide Weight Asarar Peptide Lyophilized Foda Reta Vials Allura 99% Retatrutide

Bayanin Samfura
Retatrutide sabon peptide agonist ne mai sau uku wanda ke niyya ga mai karɓar glucagon (GCGR), mai karɓar insulinotropic polypeptide mai dogaro da glucose (GIPR), da mai karɓar glucagon-kamar peptide-1 (GLP-1R). Retatrutide yana kunna GCGR na ɗan adam, GIPR, da GLP-1R tare da ƙimar EC50 na 5.79, 0.0643, da 0.775 nM, bi da bi, da linzamin kwamfuta GCGR, GIPR, da GLP-1R tare da ƙimar EC50 na 2.32, 0.0.41, da Yana aiki azaman kayan aikin bincike mai mahimmanci a cikin nazarin kiba da rikice-rikice na rayuwa.

Retatrutide yana kunna hanyar siginar GLP-1R yadda ya kamata kuma yana motsa siginar insulin mai dogaro da glucose ta hanyar aiki akan duka GIP da GLP-1 masu karɓa. Wannan peptide na roba yana nuna kaddarorin hypoglycemic mai ƙarfi kuma an ƙirƙira shi azaman fili na rigakafin ciwon sukari don Nau'in ciwon sukari na 2 (T2D). Yana haɓaka sakin insulin kuma yana hana fitar da glucagon ta hanyar dogaro da glucose.

Bugu da ƙari, an nuna Retatrutide don jinkirta zubar da ciki, rage duka azumi da matakan glucose na postprandial, rage cin abinci, da haifar da asarar nauyi a cikin mutane masu T2D.

Ayyukan Halittu
Retatrutide (LY3437943) peptide guda ɗaya ce mai haɗaɗɗiyar lipid wanda ke aiki azaman agonist mai ƙarfi na GCGR, GIPR, da GLP-1R. Idan aka kwatanta da ɗan adam glucagon da GLP-1, Retatrutide yana nuna ƙaramin ƙarfi a GCGR da GLP-1R (0.3 × da 0.4 ×, bi da bi) amma yana nuna ingantaccen ƙarfi (8.9 ×) a GIPR idan aka kwatanta da glucose-dogara insulinotropic polypeptide (GIP).

Tsarin Aiki
A cikin binciken da ya shafi berayen masu ciwon sukari tare da nephropathy, gwamnatin Retatrutide ta rage yawan albuminuria da haɓaka ƙimar tacewa ta glomerular. Ana danganta wannan tasirin kariya ga kunnawar hanyar siginar dogaro da GLP-1R/GR, wanda ke daidaita ayyukan anti-inflammatory da anti-apoptotic a cikin nama na koda.

Retatrutide kuma yana daidaita haɓakar glomerular kai tsaye, yana haɓaka ƙarfin tattara fitsari. Sakamakon farko ya nuna cewa, idan aka kwatanta da magungunan cututtukan koda na yau da kullum irin su ACE masu hanawa da ARBs, Retatrutide yana haifar da raguwa mai mahimmanci a cikin albuminuria bayan makonni hudu kawai na jiyya. Bugu da ƙari kuma, ya nuna tasiri mafi girma a cikin rage karfin jini na systolic fiye da masu hana ACE ko ARBs, ba tare da wani mummunan tasiri ba.

Side Effects
Mafi yawan illolin Retatrutide shine yanayin gastrointestinal, ciki har da tashin zuciya, gudawa, amai, da maƙarƙashiya. Waɗannan alamun gabaɗaya suna da sauƙi zuwa matsakaici kuma suna da alaƙa da warwarewa tare da rage kashi. Kusan kashi 7 cikin ɗari na batutuwa kuma sun ba da rahoton ji na tingling fata. An sami karuwar ƙwayar zuciya a cikin makonni 24 a cikin ƙungiyoyi masu girma, wanda daga baya ya koma matakan asali.