NAD + muhimmin coenzyme ne a cikin tsarin rayuwar salula, yana taka rawa ta tsakiya a cikin metabolism na makamashi, gyare-gyaren DNA da rigakafin tsufa, amsa damuwa ta salula da ka'idojin sigina, gami da neuroprotection. A cikin metabolism na makamashi, NAD + yana aiki azaman mai ɗaukar lantarki mai mahimmanci a cikin glycolysis, tricarboxylic acid sake zagayowar, da mitochondrial oxidative phosphorylation, tuki haɗin ATP da samar da makamashi don ayyukan salula. A lokaci guda, NAD + yana aiki azaman mahimmin tushe don gyaran enzymes na DNA da mai kunna sirtuins, ta haka ne ke tabbatar da kwanciyar hankali na ƙwayoyin cuta da ba da gudummawa ga tsawon rai. A ƙarƙashin yanayi na damuwa na oxidative da kumburi, NAD + yana shiga cikin hanyoyin sigina da ka'idojin calcium don adana homeostasis na salula. A cikin tsarin jin tsoro, NAD + yana goyan bayan aikin mitochondrial, yana rage lalacewar oxidative, kuma yana taimakawa jinkirta farawa da ci gaba da cututtukan neurodegenerative. Tun da matakan NAD + a zahiri suna raguwa tare da shekaru, dabarun kiyayewa ko haɓaka NAD + ana ƙara fahimtar su da mahimmanci don haɓaka lafiya da rage tsufa.