Saukewa: BPC-157
API ɗin BPC-157
BPC-157 (cikakken suna: Tsarin Kariyar Jiki 157) ɗan gajeren peptide ne na roba wanda ya ƙunshi amino acid 15, wanda aka samo daga jerin sunadaran kariya na halitta a cikin ruwan ciki na ɗan adam. Ya nuna gyare-gyaren nama mai yawa da kuma ƙarfin maganin kumburi a cikin nazarin gwaji kuma ana ɗaukarsa sosai a matsayin ɗan takarar magani na peptide multifunctional.
A matsayin mai aiki na magunguna (API), BPC-157 an yi amfani da shi a yawancin bincike na kimiyya a duniya don gano ayyukansa na nazarin halittu a cikin gastrointestinal tract, tsarin musculoskeletal, tsarin juyayi, tsarin zuciya da jijiyoyin jini da gyaran gyare-gyare mai laushi, musamman ma a cikin gyare-gyaren rauni da bincike na anti-inflammatory.
Bincike da tsarin aikin magunguna
An yi nazarin BPC-157 sosai, musamman a cikin gwaje-gwajen dabbobi na vivo da samfuran sel a cikin vitro, kuma an gano cewa yana da mahimman tasirin magunguna masu zuwa:
1. Farfadowar nama da gyaran rauni
Yana inganta jijiya, ligament, kashi da nama mai laushi, kuma yana iya haɓaka angiogenesis (angiogenesis).
Haɓaka warkar da raunuka, gyare-gyaren bayan tiyata da dawo da raunin nama mai laushi, wanda aka tabbatar da shi a cikin nau'in dabba irin su tsagewar tendon, ƙwayar tsoka, da karaya.
2. Kariyar Gastrointestinal da gyarawa
A cikin samfura irin su ciwon ciki, enteritis, da colitis, BPC-157 yana da tasirin kariya na mucosal mai mahimmanci.
Yana iya tsayayya da lalacewar gastrointestinal wanda magungunan marasa amfani da ƙwayoyin cuta (NSAIDs) suka haifar da kuma inganta warkar da mucosal na hanji.
3. Anti-mai kumburi da immunomodulatory
Yana daidaita ma'auni na tsarin rigakafi ta hanyar hana abubuwan da ke haifar da kumburi (irin su TNF-a, IL-6) da haɓaka abubuwan da ke haifar da kumburi.
Yana da yuwuwar ƙima azaman ƙarin magani don cututtukan kumburi na yau da kullun kamar ** rheumatoid arthritis da cututtukan hanji mai kumburi (IBD)**.
4. Neuroprotection da neuroregeneration
A cikin samfura bayan rauni na kashin baya, raunin jijiya, da abubuwan da ke faruwa na cerebrovascular, BPC-157 na iya inganta haɓakar jijiyoyi da rage lalacewar jijiya.
Zai iya yaki da matsaloli a cikin filin neuropsychiatric kamar damuwa, damuwa, da kuma dogara ga barasa (matakin gwaji).
5. Kariyar zuciya da jijiyoyin jini
BPC-157 na iya inganta haɓakar ƙwayoyin cuta da kuma inganta gyaran gyare-gyare na microvascular, kuma an yi imanin cewa yana da tasiri mai kyau akan cututtuka irin su ischemia na myocardial, thrombosis venous, da kuma rauni na arterial.
Sakamakon bincike na gwaji da na asibiti
Ko da yake BPC-157 ba a yarda da shi ba tukuna don magungunan likitancin ɗan adam, an nuna shi a gwaje-gwajen dabba:
Mahimman hanzarin lokacin gyaran nama (kamar 50% hanzarin warkar da tendon)
Mahimmanci rage yawan zubar jini na ciki, rauni na hanji, da ciwon hanji
Haɓaka dawo da aikin jijiya da haɓaka aikin yankin da ke ciki
Kara angiogenesis da granulation nama samuwar adadin
Saboda waɗannan sakamakon, BPC-157 yana zama mahimmancin ɗan takarar ɗan takarar bincike a cikin fa'idodin gyaran gyare-gyare na baya-bayan nan, raunin wasanni, cututtukan gastrointestinal, da cututtukan neurodegenerative.
Samar da API da sarrafa inganci
API ɗin BPC-157 da Rukunin Gentolex ɗinmu ya samar yana ɗaukar ingantaccen tsarin haɗin lokaci (SPPS) kuma ana samarwa a ƙarƙashin yanayin GMP. Yana da halaye kamar haka:
Babban tsabta: ≥99% (Gano HPLC)
Ragowar ƙazanta maras nauyi, babu endotoxin, babu gurɓataccen ƙarfe
Tsayayyen tsari, maimaituwa mai ƙarfi, goyan bayan amfani matakin allura
Taimakawa samar da matakan gram da kilogiram don biyan bukatun matakai daban-daban daga R&D zuwa masana'antu.
