Cagrilintide

API ɗin Cagrilintide

Cagrilintidewani dogon aiki ne, an haɗa shi da sinadaraiamylin receptor agonist, ci gaba a matsayin novel magani gakiba da cututtukan da ke da alaƙa da nauyi. An tsara shi don kwaikwayi tasirinadam amylin, wani hormone da aka haɗa tare da insulin ta hanyar ƙwayoyin β-pancreatic, wanda ke taka muhimmiyar rawa wajen daidaita abincin abinci, zubar da ciki, da satiety.

Ana haɓaka Cagrilintide azaman maimaganin allura sau ɗaya a mako, miƙa wani sosai alamar rahama bayani gana kullum nauyi management, musamman idan aka yi amfani da suhade tare da GLP-1 agonists mai karɓakamarSemaglutide.

Tsarin Aiki

Cagrilintide yana aiwatar da tasirinsa na warkewa ta hanyar ɗaurewa da kunnawaamylin receptors, kai ga:

• Ciwon kai

• Jinkirta zubar ciki, wanda ke tsawaita jin cikar

• Rage yawan abincin kalori da ƙara yawan satiety

Wannan ƙa'ida ta multimodal na cin abinci ya sa ya zama kyakkyawan ɗan takara don sarrafawakiba da alaƙar cardiometabolic.

Bincike da Bayanan Asibiti

Cagrilintide ya nuna sakamako mai ban sha'awa a cikin gwaje-gwajen asibiti da yawa, ciki har daNazarin mataki na 2 wanda Novo Nordisk ya gudanar:

• Lokacin amfanikadai, Cagrilintide yana haifar daasarar nauyi mai dogaro da kashi, tare da har zuwa10.8% rage nauyin jikisama da makonni 26 a cikin mutane masu kiba.

• Yaushehade da Semaglutide, An inganta tasirin asarar nauyi sosai-cimmamafi girma raguwa a cikin nauyin jiki fiye da ko dai wakili kadai.

• Ya nunam haƙurikumabayanin martaba mai dorewa, tare da mafi yawan abubuwan da ba su da kyau sune alamun cututtuka na gastrointestinal.

Wannan hanyar haɗin gwiwa wani mahimmin sashi ne nabututun maganin kiba mai zuwa na gaba, niyya hanyoyin satiety da yawa (amylin + GLP-1).

API Quality da Manufacturing

MuAPI ɗin Cagrilintide:

• Ana samarwa ta hanyar ci gabaTsarin peptide mai ƙarfi (SPPS)tare da babban tsabta da kwanciyar hankali na sinadarai

• An tsara donci gaban tsarin injectable

• Haɗu da ƙasashen duniyaMa'aunin magunguna (ICH, GMP, FDA)

• Akwai a cikimatukin jirgi don samar da sikelin kasuwanci, dace da asibiti da kuma masana'antu amfani

Yiwuwar warkewa

Cagrilintide yana wakiltar alabari injia cikin sarrafa nauyi fiye da GLP-1 monotherapy. Bayanin bayanan aikin sa na haɗin gwiwa ya sa ya dace da:

• Kiba da kiba marasa lafiya(tare da ko ba tare da ciwon sukari)

• Magungunan haɗin gwiwadon haɓaka asarar nauyi

• Ci gaban gaba aMetabolism syndrome da prediabetes