Caspofungin don kamuwa da cututtukan fungal
Cikakken Bayani
| Suna | Caspofungin |
| Lambar CAS | 162808-62-0 |
| Tsarin kwayoyin halitta | Saukewa: C52H88N10O15 |
| Nauyin kwayoyin halitta | 1093.31 |
| Lambar EINECS | 1806241-263-5 |
| Wurin tafasa | 1408.1 ± 65.0 °C (An annabta) |
| Yawan yawa | 1.36 ± 0.1 g/cm3 (An annabta) |
| Yawan acidity | (pKa) 9.86± 0.26 (An annabta) |
Makamantu
CS-1171; Caspofungine; CASPOFUNGIN; CASPORFUNGIN; PneuMocandinB0,1-[(4R,5S) -5-[(2-aMinoethyl) aMino] -N2- (10,12-diMethyl-1-oxotetradecyl) -4-hydroxy- L-ornithine] -5-[(3R) -3-hydroxy-L-ornithine] -; CaspofunginMK-0991; Aids058650; Aids-058650
Abubuwan Sinadarai
Caspofungin shine echinocandin na farko da aka amince da shi don maganin cututtukan cututtukan fungal.Gwaje-gwajen in vitro da in vivo sun tabbatar da cewa caspofungin yana da kyawawan ayyukan kashe ƙwayoyin cuta a kan mahimman ƙwayoyin cuta masu dama-Candida da Aspergillus.Caspofungin na iya rushe bangon tantanin halitta ta hanyar hana haɗin 1,3-β-glucan.A asibiti, caspofungin yana da kyau sakamako a kan lura da daban-daban candidiasis da aspergillosis.
Tasiri
(1,3) -D-glucan synthase shine maɓalli mai mahimmanci na haɗin bangon ƙwayar fungal, kuma caspofungin na iya yin tasirin antifungal ta hanyar hana cin nasara ga wannan enzyme.Bayan gudanar da jijiya, ƙwayar ƙwayar ƙwayar ƙwayar cuta ta plasma tana raguwa da sauri saboda rarrabawar nama, sannan a sake sakin maganin a hankali daga nama.Metabolism na caspofungin ya karu tare da karuwar kashi kuma yana da alaƙa da kashi a cikin lokacin da za a daidaita tare da allurai masu yawa.Sabili da haka, don cimma ingantattun matakan warkewa da kuma guje wa tarawar ƙwayoyi, yakamata a gudanar da kashi na farko na ɗaukar nauyi sannan kuma adadin kulawa.Lokacin amfani da cytochrome p4503A4 inducers a lokaci guda, kamar rifampicin, carbamazepine, dexamethasone, phenytoin, da dai sauransu, ana bada shawara don ƙara yawan adadin caspofungin.
Alamomi
Abubuwan da FDA ta amince da su na caspofungin sun haɗa da: 1. Zazzaɓi tare da neutropenia: an bayyana shi azaman: zazzabi> 38 ° C tare da cikakken adadin neutrophil (ANC) ≤500 / ml, ko tare da ANC ≤1000 / ml kuma an annabta cewa za a iya rage shi. zuwa kasa da 500/ml.Bisa ga shawarar da Cibiyar Cututtuka ta Amurka (IDSA), ko da yake an yi wa marasa lafiya da zazzabi mai tsanani da kuma neutropenia maganin rigakafi mai yawa, har yanzu ana ba da shawarar marasa lafiya masu haɗari su yi amfani da maganin antifungal na empiric, ciki har da caspofungin da sauran magungunan antifungal. ..2. Invasive candidiasis: IDSA yana ba da shawarar echinocandins (irin su caspofungin) azaman magani na zabi don candidemia.Hakanan za'a iya amfani da ita don magance ƙurar ciki, peritonitis da cututtukan ƙirji wanda kamuwa da cutar Candida ke haifarwa.3. Candidiasis na Esophageal: Ana iya amfani da Caspofungin don magance cututtuka na esophageal candidiasis a cikin marasa lafiya tare da refractory ko rashin haƙuri ga wasu hanyoyin kwantar da hankali.Yawancin karatu sun gano cewa tasirin warkewa na caspofungin yana kama da na fluconazole.4. Aspergillosis mai haɗari: An yarda da Caspofungin don maganin aspergillosis mai haɗari a cikin marasa lafiya tare da rashin haƙuri, juriya, da rashin tasiri na babban maganin antifungal, voriconazole.Duk da haka, ba a ba da shawarar echinocandin azaman farfagandar layin farko ba.
