Donidalorsen

Donidalorsen (API)

Aikace-aikacen Bincike:
Donidalorsen API wani maganin antisense oligonucleotide (ASO) ne a ƙarƙashin bincike don maganin angioedema na gado (HAE) da kuma yanayin kumburi masu alaƙa. Ana nazarin shi a cikin mahallin hanyoyin kwantar da hankali na RNA, da nufin rage bayyanar cututtukaplasma prekallikrein(KLKB1 mRNA). Masu bincike suna amfani da Donidalorsen don bincika hanyoyin yin shiru na kwayoyin halitta, magunguna masu dogara da kashi, da kuma kulawa na dogon lokaci na kumburi mai shiga tsakani na bradykinin.

Aiki:
Donidalorsen yana aiki ta zaɓin ɗaure zuwaKLKB1mRNA, rage samar da plasma prekallikrein - wani mahimmin enzyme a cikin tsarin kallikrein-kinin da ke da alhakin haifar da kumburi da kumburi a cikin HAE. Ta hanyar rage matakan kallikrein, Donidalorsen yana taimakawa hana hare-haren HAE kuma yana rage nauyin cututtuka. A matsayin API, yana aiki azaman ɓangarorin ɓangarorin warkewa a cikin haɓaka dogon aiki, jiyya da ake gudanarwa ta subcutaneously don HAE.