Fitusiran

Fitusiran (API)

Aikace-aikacen Bincike:
Fitusiran API wani ƙaramin RNA ne mai tsoma baki (siRNA) wanda aka bincika da farko a fagen cutar haemophilia da rikicewar coagulation. Yana kaiwa hariAntithrombin (AT ko SERPINC1)kwayoyin halitta a cikin hanta don rage samar da antithrombin. Masu bincike suna amfani da Fitusiran don bincika hanyoyin tsangwama na RNA (RNAi), takamaiman ƙwayoyin halittar hanta, da sabbin dabarun warkewa don sake daidaita coagulation a cikin marasa lafiya na hemophilia A da B, tare da ko ba tare da masu hanawa ba.

Aiki:
Fitusiran yana aiki ta hanyar rufe maganganun antithrombin, maganin rigakafi na halitta, wanda hakan yana haɓaka haɓakar thrombin da haɓaka samuwar jini. Wannan tsarin yana ba da tsarin kulawa na rigakafi don rage zubar jini a cikin marasa lafiya na hemophilia. A matsayin API, Fitusiran yana aiki a matsayin sinadari mai aiki a cikin dogon aiki na jiyya na subcutaneous da nufin inganta ingancin rayuwa da rage nauyin jiyya a cikin cututtukan jini.