Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Aikace-aikacen Bincike:
Wannan fili shine kariyar lysine mai aiki, wanda aka yi amfani da shi a cikin haɗin peptide da haɓaka haɗin magunguna. Yana fasalta ƙungiyar Fmoc don kariyar N-terminal, da gyare-gyare na gefe tare da Eic (OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), da AEEA (aminoethoxyethoxyacetate). An ƙera waɗannan abubuwan haɗin gwiwa don nazarin tasirin lipidation, sinadarai ta sarari, da sakin magunguna masu sarrafawa. An yi bincike sosai a cikin mahallin dabarun samar da magunguna, masu haɗin ADC, da peptides masu mu'amala da membrane.

Aiki:
Fmoc-L-Lys [Eic(OtBu) -γ-Glu(OtBu)-AEEA] -OH yana aiki azaman tubalin gini don haɗa peptides da aka gyara na lipid ko tsarin isar da magunguna. Tsarin Eic yana inganta lipophilicity da ɗaurin membrane; γ-Glu yana ƙara kwanciyar hankali na enzymatic da yuwuwar niyya; kuma AEEA yana aiki azaman mai haɗin hydrophilic mai sassauƙa. Tare, suna ba da damar gina peptides tare da haɓaka haɓakar salon salula, tsawaita rabin rayuwa, da ƙayyadaddun kayan isar da wurin.