Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Aikace-aikacen Bincike:
Wannan fili wani nau'in lysine ne da aka gyara wanda aka yi amfani da shi a cikin haɗin peptide, musamman don gina haɗin gwiwar peptide da aka yi niyya ko multifunctional. Ƙungiyar Fmoc tana ba da damar yin kira ta hanyar mataki ta hanyar Fmoc solid-phase peptide synthesis (SPPS). An gyaggyara sarkar gefen tare da stearic acid wanda aka samu (Ste), γ-glutamic acid (γ-Glu), da masu haɗin AEEA guda biyu (aminoethoxyethoxyethoxyacetate), waɗanda ke ba da hydrophobicity, kaddarorin caji, da tazara mai sassauƙa. Ana yawan nazarin shi don rawar da yake takawa a cikin tsarin isar da magunguna, gami da haɗin gwiwar magungunan rigakafi (ADCs) da peptides masu shiga tantanin halitta.

Aiki:
Fmoc-L-Lys [Ste(OtBu) -γ-Glu(OtBu) -AEEA-AEEA] -OH yana aiki azaman tubalan gini don haɓaka peptides masu lipid mai tsayin sarkar ko hadaddun masu haɗa magunguna. Stearic acid yana haɓaka alaƙar membrane, γ-Glu yana haɓaka kwanciyar hankali da juriya na enzymatic, kuma masu haɗin AEEA suna ba da solubility da sassaucin tsari. Tare, waɗannan fasalulluka suna ba da fili mai daraja a ƙirƙira peptides don ingantacciyar rayuwa, sakin sarrafawa, da aikace-aikacen isar da niyya.