Fmoc-Thr(tBu) -Phe-OH

Fmoc-Thr(tBu) -Phe-OH

Aikace-aikacen Bincike:
Fmoc-Thr(tBu) -Phe-OH tubalin ginin dipeptide ne wanda aka saba amfani dashi a cikin hadadden peptide synthesis (SPPS). Ƙungiyar Fmoc (9-fluorenylmethyloxycarbonyl) tana kare N-terminus, yayin da ƙungiyar tBu (tert-butyl) ke kare sarkar gefen hydroxyl na threonine. Ana nazarin wannan kariya ta dipeptide don rawar da yake takawa wajen sauƙaƙe haɓakar haɓakar peptide mai inganci, rage tseren tsere, da ƙirar ƙayyadaddun ƙayyadaddun jigogi a cikin tsarin furotin da nazarin hulɗa.

Aiki:
Fmoc-Thr (tBu) -Phe-OH yana aiki azaman mafari don haɗakar da peptides waɗanda suka haɗa da ragowar threonine da phenylalanine, waɗanda ke da mahimmanci don ƙirƙirar haɗin hydrogen da hulɗar hydrophobic. Sarkar gefen threonine yana ba da gudummawar polarity da yuwuwar wuraren phosphorylation, yayin da phenylalanine yana ƙara halayen ƙanshi da kwanciyar hankali. Wannan haɗin yana da amfani wajen ƙirƙira peptides don ƙididdigar ilimin halitta, nazarin ɗaure mai karɓa, da aikace-aikacen gano magunguna.