Ciwon sodium

Inclisiran Sodium (API)

Aikace-aikacen Bincike:
Inclisiran sodium API (Active Pharmaceutical Ingredient) ana nazarinsa da farko a fagen tsoma bakin RNA (RNAi) da kuma hanyoyin kwantar da hankali na zuciya. A matsayin siRNA mai madauri biyu da ke niyya ga kwayar PCSK9, ana amfani da shi a cikin bincike na gaskiya da na asibiti don kimanta dabarun yin shiru na dogon aiki don rage LDL-C (cholesterol mai ƙarancin yawa). Hakanan yana aiki azaman abin ƙira don bincika tsarin isar da siRNA, kwanciyar hankali, da magungunan RNA mai niyya da hanta.

Aiki:
Inclisiran sodium API yana aiki ta hanyar kashe kwayar PCSK9 a cikin hanta, yana haifar da raguwar samar da furotin PCSK9. Wannan yana haifar da ingantaccen sake amfani da masu karɓar LDL da mafi girman sharewar LDL cholesterol daga jini. Ayyukansa azaman wakili mai rage ƙwayar cholesterol mai tsayi yana tallafawa amfani da shi wajen magance hypercholesterolemia da rage haɗarin cututtukan zuciya. A matsayin API, yana samar da ainihin abin da ke aiki a cikin ƙirar magunguna na tushen Inclisiran.