Ipamorelin

Ipamorelin API

Ipamorelin shine hormone pentapeptide na roba wanda ke sakin peptide (GHRP) wanda ya ƙunshi amino acid guda biyar (Aib-His-D-2-Nal-D-Phe-Lys-NH₂). Yana da zaɓi na GHSR-1a agonist tare da ikon haɓaka haɓakar haɓakar hormone (GH) tare da ƙayyadaddun ƙayyadaddun ƙayyadaddun abubuwa. Idan aka kwatanta da GHRPs na baya (irin su GHRP-2 da GHRP-6), Ipamorelin yana nuna mafi kyawun zaɓi, aminci da kwanciyar hankali na pharmacological ba tare da tasiri sosai akan matakan wasu kwayoyin halitta irin su cortisol, prolactin ko ACTH ba.

A matsayin API na peptide da ake la'akari sosai, Ipamorelin a halin yanzu ana amfani dashi sosai a cikin bincike na tsufa, gyaran wasanni, tsoma baki na osteoporosis, farfadowa na baya da kuma tsarin aiki na rayuwa.

Bincike da Tsarin Aiki

Ipamorelin yana haɓaka sakin hormone girma na endogenous (GH) daga pituitary na baya ta hanyar zaɓin kunna mai karɓar haɓakar haɓakar haɓakar ƙwayar cuta (GHSR-1a) da yin kwaikwayon aikin ghrelin. Manyan hanyoyin sarrafa magunguna sun haɗa da:
1. Ƙarfafa ƙwayar GH
Ipamorelin yana zabar GHSR-1a sosai, yana haifar da glandon pituitary don saki GH ba tare da tasiri sosai akan matakan ACTH ko cortisol ba, kuma yana da mafi kyawun amincin endocrin.
2. Haɓaka haɗin furotin da gyaran sel
Ta hanyar haɓaka matakan IGF-1, yana inganta anabolism cell cell, yana inganta gyaran gyare-gyaren nama da farfadowa, kuma ya dace da gyaran gyare-gyaren rauni, farfadowa na tiyata da maganin atrophy na tsoka.
3. Inganta metabolism da rarraba mai
GH yana da tasirin tattara kitse da haɓaka ƙwarewar insulin. Ipamorelin na iya taimakawa wajen daidaita yanayin rayuwa kuma ana amfani dashi a cikin bincike akan ciwo na rayuwa da kuma kiba.
4. Inganta girman kashi da rigakafin tsufa
GH / IGF-1 axis na iya inganta haɓakar kashi da kuma ma'adinai. Ipamorelin yana nuna alƙawarin a cikin maganin osteoporosis, gyaran karaya da kuma tsufa.
5. Inganta rhythm na circadian da ingancin barci
Sakin GH yawanci yana tare da barci mai zurfi. Nazarin ya gano cewa Ipamorelin na iya inganta tsarin barci a kaikaice kuma ya inganta karfin farfadowa na jiki.
Nazarin preclinical da tabbatar da inganci

Ko da yake har yanzu a cikin matakin farko / farkon asibiti, Ipamorelin ya nuna kyakkyawan aminci da inganci a cikin dabba da wasu nazarin ɗan adam:

Matakan GH suna ƙaruwa sosai (kololuwa a cikin mintuna 30, yana dawwama na sa'o'i da yawa)

Babu tabbataccen tasirin pro-cortisol ko pro-ACTH, tasirin endocrin sun fi iya sarrafawa

Inganta yawan tsoka da ƙarfi (musamman a cikin tsofaffin dabbobin dabbobi)

Inganta farfadowa bayan tiyata da saurin gyaran nama

Ƙara matakan IGF-1 yana taimakawa gyaran salula da amsawar antioxidant

Bugu da ƙari, Ipamorelin tare da sauran GHRH mimetics (irin su CJC-1295) a cikin wasu nazarin ya nuna tasirin haɗin gwiwa, yana ƙara haɓaka bugun jini na GH.
Samar da API da tabbacin inganci

An shirya Ipamorelin API ta ƙungiyar Gentolex ɗinmu ta amfani da tsari mai ƙarfi ** m lokaci peptide synthesis process (SPPS)**, kuma an tsarkake shi sosai kuma an gwada ingancinsa, dacewa da bincike na kimiyya da haɓakawa da farkon amfani da bututun magunguna na kamfanonin harhada magunguna.

Siffofin samfur sun haɗa da:

Tsafta ≥99% (gwajin HPLC)
Babu endotoxin, ƙarancin sauran ƙarfi, ƙarancin ƙarancin ƙarfe ion
Samar da cikakken saitin ingantattun takardu: COA, rahoton nazarin kwanciyar hankali, nazarin bakan ƙazanta, da sauransu.
Matsakaicin wadatar matakin-gram~kilogram