MOTS-C

Takaitaccen Bayani:

MOTS-C API an samar da shi a ƙarƙashin tsauraran yanayin GMP-kamar ta amfani da fasaha mai ƙarfi peptide kira (SPPS) don tabbatar da ingancinsa mai girma, babban tsabta da kwanciyar hankali don bincike da amfani da warkewa.
Siffofin samfur:

Tsafta ≥ 99% (HPLC da LC-MS sun tabbatar),
Low endotoxin da sauran sauran ƙarfi abun ciki,
An samar da shi daidai da ICH Q7 da ka'idojin GMP,
Za a iya cimma babban samarwa, daga matakin miligram-R&D batches zuwa matakin-gram da wadatar kasuwancin kilogiram.

Aika mana imel

Cikakken Bayani

Tags samfurin

MOTS-C API

MOTS-C(Mitochondrial Buɗaɗɗen Karatun Karatu na 12S rRNA Type-c) shine amino acid 16.peptide-wanda aka samu mitochondria (MDP)wanda aka sanya ta hanyar genome mitochondrial. Ba kamar peptides na al'ada na nukiliya ba, MOTS-c ya samo asali ne daga yankin 12S rRNA na DNA na mitochondrial kuma yana taka muhimmiyar rawa a cikindaidaita metabolism na salula, amsa damuwa, da kuma insulin hankali.

A matsayin novel therapeutic peptide,MOTS-c APIya samu gagarumin sha'awa a fagagencututtuka na rayuwa, tsufa, motsa jiki physiology, da magungunan mitochondrial. A halin yanzu peptide yana ƙarƙashin bincike mai zurfi kuma ana ɗaukarsa a matsayin ɗan takara mai ban sha'awana gaba-tsara peptide therapeuticsniyya ga lafiyar jiki da kuma tsawon rai.

Tsarin Aiki

MOTS-c yana aiwatar da tasirin sa ta hanyarmitochondrial-nukiliya giciye magana-Hanyar da mitochondria ke sadarwa tare da tsakiya don kula da homeostasis na salula. Ana canza peptide daga mitochondria zuwa tsakiya don amsa damuwa na rayuwa, inda yake aiki azamanmetabolism regulatorta hanyar rinjayar maganganun kwayoyin halitta.

Mahimman hanyoyin nazarin halittu sun haɗa da:

Kunna AMPK (AMP-activated protein kinase):MOTS-c yana ƙarfafa AMPK, firikwensin makamashi na tsakiya, haɓakawashan glucose, fatty acid oxidation, da mitochondrial biogenesis.
Haɓaka ji na insulin:MOTS-c yana haɓaka amsawar insulin a cikin tsoka da ƙwayar adipose, haɓakawaglucose homeostasis.
Ƙunƙarar damuwa na oxidative da kumburi:Ta hanyar daidaita ma'aunin redox na salula da hanyoyin siginar kumburi.
Dokokin aikin mitochondrial da biogenesis:Yana goyan bayan lafiyar mitochondrial, musamman a ƙarƙashin damuwa ko yanayin tsufa.

Binciken Jiyya da Tasirin Halittu

Nazarin preclinical sun nuna nau'ikan tasirin ilimin lissafi da na warkewa na MOTS-c a cikin duka in vitro da samfuran dabba:

1. Rikicin Metabolic (Kiba, Nau'in Ciwon sukari Na 2, Resistance Insulin)

Yana inganta haƙurin glucose kuma yana rage matakan glucose na jini
Yana haɓakawainsulin sensitivityba tare da haɓaka matakan insulin ba
Yana haɓakaasarar nauyi da oxidation maia cikin mice masu kiba da ke haifar da abinci

2. Anti-Tsafa da Tsawon Rayuwa

Matakan MOTS-c suna raguwa tare da shekaru, kuma an nuna ƙarin a cikin tsofaffin berayenƙara ƙarfin jiki, inganta aikin mitochondrial, kumajinkirta raguwar shekaru masu alaƙa.
Yana inganta aikin motsa jiki dajuriyar tsokata hanyar inganta oxidative metabolism.

3. Kariyar damuwa na Mitochondrial da Salon salula

Yana haɓakawarayuwa ta salula a ƙarƙashin damuwa na rayuwa ko oxidativeyanayi.
Yana ƙara bayyanar kwayoyin halitta masu alaƙa dagyaran salula da autophagy.

4. Ciwon Jiji da Jikin Jiki da Ƙarfin Neuro

Nazarin farko ya nuna MOTS-c na iya karewaKwayoyin endothelial na jijiyoyin jinida rage alamun damuwa na zuciya.
Abubuwan da ke da yuwuwar neuroprotective ta hanyarhanyoyin anti-mai kumburi da antioxidativeana bincike.

API Kerawa da Halayen Inganci

At Gentolex Group, muMOTS-c APIana yin amfani da shiTsarin peptide mai ƙarfi (SPPS)a ƙarƙashin tsauraran yanayi kamar GMP, yana tabbatar da inganci, tsabta, da kwanciyar hankali don bincike da amfani da warkewa.