GH / IGF-1 yana rage physiologically tare da shekaru, kuma waɗannan canje-canje suna tare da gajiya, atrophy na tsoka, ƙara yawan ƙwayar adipose, da kuma rashin fahimta a cikin tsofaffi ...
A cikin 1990, Rudman ya buga wata takarda a cikin New England Journal of Medicine wanda ya gigice al'ummar likitanci - "Amfani da Hormone na Ci gaban Dan Adam a cikin Mutane Sama da Shekaru 60".Rudman ya zaɓi maza 12 masu shekaru 61-81 don gwaji na asibiti:
Bayan watanni 6 na allurar hGH, batutuwa suna da matsakaicin haɓaka na 8.8% a cikin ƙwayar tsoka, 14.4% a cikin asarar mai, 7.11% a cikin fata mai kauri, 1.6% a cikin yawan kashi, 19% a cikin hanta da 17% a cikin hanta idan aka kwatanta da sarrafawa. rukunin sauran tsofaffi masu shekaru daya.%, an kammala cewa canje-canje na tarihi a cikin duk batutuwa sun kasance 10 zuwa 20 shekaru matasa.
Wannan ƙarshe ya haifar da haɓaka haɓakar haɓakar haɓakar haɓakar ɗan adam (rhGH) a matsayin maganin rigakafin tsufa, kuma shine tushen tushen imanin mutane da yawa cewa allurar rhGH na iya hana tsufa.Tun daga wannan lokacin, yawancin likitocin sun yi amfani da hGH a matsayin maganin tsufa, kodayake FDA ba ta amince da su ba.
Duk da haka, yayin da bincike ya ci gaba da zurfafawa, masana kimiyya sun gano cewa ƙananan amfani ga jiki na ƙara yawan aikin GH / IGF-1 axis ba ya tsawanta rayuwar tsofaffi, amma a maimakon haka yana haifar da haɗari ga lafiya:
Mice oversecreting GH suna da girma, amma suna da 30% -40% gajeriyar rayuwa fiye da nau'in berayen daji [2], da canje-canje na tarihi (glomerulosclerosis da yaduwar hanta) suna faruwa a cikin mice tare da matakan GH masu girma.babba) da juriya na insulin.
Babban matakan GH yana haɓaka haɓakar tsokoki, ƙasusuwa, da gabobin ciki, yana haifar da gigantism (a cikin yara) da acromegaly (a cikin manya).Manya da wuce haddi GH ana danganta su da ciwon sukari da matsalolin zuciya, da kuma haɗarin ciwon daji mafi girma.
Lokacin aikawa: Jul-22-2022