Retatrutide yana juyi yadda ake kula da kiba

A cikin al'ummar yau, kiba ya zama kalubalen kiwon lafiya a duniya, da bullowarRetatrutideyana ba da sabon bege ga marasa lafiya da ke fama da nauyi mai yawa. Retatrutide shine aSau uku agonist mai karɓaniyyaGLP-1R, GIPR, da GCGR. Wannan keɓantaccen tsarin haɗin kai mai maƙasudi da yawa yana nuna babban yuwuwar asarar nauyi.

Mechanistically, Retatrutide yana kunnawaGLP-1 masu karɓa, wanda ke inganta siginar insulin, yana hana sakin glucagon, da jinkirta zubar da ciki, ta yadda zai kara yawan gamsuwa da rage cin abinci. Kunnawa naMasu karɓar GIPyana ƙara haɓaka ƙwarewar insulin, yana daidaita metabolism na lipid, kuma yana aiki tare tare da GLP-1 don haɓaka tasirin rage nauyi. Mafi mahimmanci, kunnawa naMasu karɓar glucagon (GCGR)yana ƙara yawan kashe kuzari, yana haɓaka hanawar gluconeogenesis na hanta, kuma yana rage yawan kitsen hanta-tare, waɗannan hanyoyin suna ba da gudummawa ga asarar nauyi mai yawa.

A cikin gwaje-gwajen asibiti, sakamakon asarar nauyi na Retatrutide ya kasance na ban mamaki. A cikin binciken asibiti na mako 48 na Phase 2, mahalarta da ke karɓar kashi 12 na MG na Retatrutide na mako-mako sun rasa matsakaicin.24.2% na nauyin jikinsu-sakamakon da ya wuce yawancin magungunan rage nauyi na gargajiya da kuma kusanci ingancin aikin tiyatar bariatric. Bugu da ƙari, asarar nauyi yana ci gaba da ingantawa a tsawon lokaci; tamako na 72, matsakaicin raguwar nauyi ya kai kusan28%.

Bayan tasirinsa mai ƙarfi na rage nauyi, Retatrutide kuma yana nuna babban alƙawarin inganta rikice-rikice masu alaƙa da kiba. Yana iya rage hawan jini, inganta bayanan martaba, rage matakan triglyceride, kuma yana ba da kariya ta zuciya - yana kawowa.cikakken amfanin lafiyaga mutanen da ke fama da kiba.