-
Cikakken suna:Ginin Kariyar Jiki-157, apentadecapeptide (15-amino acid peptide)asali keɓe daga ruwan ɗan adam na ciki.
-
Amino acid tsarin:Gly-Glu-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val, Nauyin kwayoyin halitta ≈ 1419.55 Da.
-
Idan aka kwatanta da sauran peptides da yawa, BPC-157 yana da ingantacciyar kwanciyar hankali a cikin ruwa da ruwan 'ya'yan itace na ciki, wanda ke sa gudanarwar baki ko na ciki ta fi dacewa.
Hanyoyin Ayyuka
-
Angiogenesis / Ciwon Jiki
-
Abubuwan haɓakawaVEGFR-2magana, inganta sabon samuwar jini.
-
Kunna daHanyar Src-Caveolin-1-eNOS, yana haifar da sakin nitric oxide (NO), vasodilation, da ingantaccen aikin jijiyoyin jini.
-
-
Anti-mai kumburi & Antioxidant
-
Downregulates pro-inflammatory cytokines kamarIL-6kumaTNF-a.
-
Yana rage samar da nau'in iskar oxygen (ROS) mai amsawa, yana kare sel daga damuwa na iskar oxygen.
-
-
Gyaran Nama
-
Yana haɓaka tsari da farfadowa na aiki a cikin jijiya, jijiya, da ƙirar raunin tsoka.
-
Yana ba da kariya ga neuroprotection a cikin tsarin raunin da ya faru na tsakiya (cututtuka na kashin baya, ƙwaƙwalwar ƙwayar cuta-reperfusion), rage mutuwar neuronal da inganta motsi / jiyya.
-
-
Ka'idar Sautin Jijiya
-
Ex vivo vascular Nazarin nuna BPC-157 haifar da vasorelaxation, dogara a kan m endothelium da NO hanyoyi.
-
Dabbobi & In Vitro Comparative Data
| Nau'in Gwaji | Model / Tsangwama | Kashi / Gudanarwa | Sarrafa | Mabuɗin Sakamako | Bayanin Kwatancen |
|---|---|---|---|---|---|
| Vasodilation (bera aorta, ex vivo) | Phenylephrine-precontracted aortic zobba | BPC-157 har zuwa100 μg/ml | Babu BPC-157 | Vasorelaxation ~37.6 ± 5.7% | Rage zuwa10.0 ± 5.1% / 12.3 ± 2.3%tare da mai hana NOS (L-NAME) ko NO scavenger (Hb) |
| Gwajin Kwayoyin Endothelial (HUVEC) | Al'adun HUVEC | 1 μg/ml | Ikon sarrafawa mara magani | ↑ BABU samarwa (1.35 - ninka); ↑ hijirar tantanin halitta | An soke hijira tare da Hb |
| Samfurin hannu na Ischemic (bera) | Hindlimb ischemia | 10 μg/kg/rana (ip) | Babu magani | Saurin dawo da kwararar jini, ↑ angiogenesis | Jiyya > Sarrafa |
| Matsewar kashin baya (bera) | Sacrococcygeal kashin baya matsawa | Allurar ip guda 10 min bayan rauni | Ƙungiyar marasa magani | Muhimmancin neurological da farfadowa da tsarin | Ƙungiyar sarrafawa ta kasance gurgu |
| Samfurin Hepatotoxicity (CCl ₄ / barasa) | Raunin hanta ta hanyar sinadari | 1 μg ko 10 ng/kg (ip / baka) | Ba a yi masa magani ba | ↓ AST / ALT, rage necrosis | Ƙungiyar kulawa ta nuna mummunan rauni na hanta |
| Nazarin guba | Mice, zomaye, karnuka | Yawan allurai / hanyoyi | Gudanar da Placebo | Babu mahimmancin guba, ba a lura da LD₅₀ ba | Da kyau jure ko da a high allurai |
Nazarin Dan Adam
-
Jerin shari'a: Intra-articular injection na BPC-157 a cikin 12 marasa lafiya tare da ciwon gwiwa → 11 ya ruwaito gagarumin taimako na jin zafi. Iyakance: babu ƙungiyar sarrafawa, babu makanta, sakamako na zahiri.
-
Gwajin asibiti: An gudanar da nazarin aminci da magunguna na Phase I (NCT02637284) a cikin masu aikin sa kai na lafiya 42, amma ba a buga sakamakon ba.
A halin yanzu,babu ingantattun gwajin sarrafa bazuwar (RCTs)akwai don tabbatar da inganci da aminci na asibiti.
Tsaro & Hatsari masu yuwuwa
-
Angiogenesis: Amfani don warkarwa, amma yana iya inganta haɓakar ƙwayar cuta, haɓaka haɓaka ko metastasis a cikin masu ciwon daji.
-
Kashi & Gudanarwa: Yana da tasiri a cikin dabbobi a ƙananan allurai (ng-µg/kg), amma mafi kyawun adadin ɗan adam da hanya ba a bayyana su ba.
-
Amfani na dogon lokaci: Babu cikakkun bayanai masu guba na dogon lokaci; yawancin karatu na ɗan gajeren lokaci ne.
-
Matsayin tsari: Ba a yarda da shi azaman magani ba a yawancin ƙasashe; classified as aharamun abuta WADA (Hukumar Yaki da Doping ta Duniya).
Halayen Kwatancen & Iyakance
| Kwatanta | Ƙarfi | Iyakance |
|---|---|---|
| Dabba vs Mutum | Daidaitaccen tasiri mai amfani a cikin dabbobi (jijiya, jijiyoyi, gyaran hanta, angiogenesis) | Shaidar ɗan adam kaɗan ce, ba ta da iko, kuma ba ta da dogon lokaci |
| Yawan adadin | Tasiri a ƙananan allurai a cikin dabbobi (ng-µg/kg; µg/ml in vitro) | Amintaccen maganin ɗan adam wanda ba a sani ba |
| Farkon aiki | Gudanarwa na farko bayan raunin da ya faru (misali, 10 min bayan rauni na kashin baya) yana haifar da farfadowa mai karfi | Ba a san yuwuwar asibiti na irin wannan lokacin ba |
| Guba | Babu wani kashi mai kisa ko mummunan tasirin da aka samu a cikin nau'ikan dabbobi da yawa | Ba a gwada guba na dogon lokaci, cutar sankarau, da amincin haihuwa ba |
Kammalawa
-
BPC-157 yana nuna tasirin farfadowa mai ƙarfi da kariya a cikin dabbobi da samfuran tantanin halitta: angiogenesis, anti-kumburi, gyaran nama, neuroprotection, da hepatoprotection.
-
Shaidar ɗan adam tana da iyaka, ba tare da ingantaccen bayanan gwaji na asibiti ba.
-
Bugu da karigwaje-gwajen sarrafa bazuwar da aka tsara da kyauana buƙatar kafa inganci, aminci, mafi kyawun allurai, da hanyoyin gudanarwa a cikin mutane.
Lokacin aikawa: Satumba-23-2025