NAD⁺ (Nicotinamide Adenine Dinucleotide) wani muhimmin coenzyme ne da ke cikin kusan dukkanin sel masu rai, galibi ana kiranta da "kwallin kwayar halitta mai mahimmancin salon salula." Yana aiki da ayyuka da yawa a cikin jikin ɗan adam, yana aiki azaman mai ɗaukar kuzari, mai kula da kwanciyar hankali na kwayoyin halitta, da kuma mai kare aikin salula, yana mai da mahimmanci don kiyaye lafiya da jinkirta tsufa.
A cikin metabolism na makamashi, NAD⁺ yana sauƙaƙe jujjuya abinci zuwa makamashi mai amfani. Lokacin da carbohydrates, fats, da sunadarai suka rushe a cikin sel, NAD⁺ yana aiki azaman mai ɗaukar lantarki, yana canza kuzari zuwa mitochondria don fitar da samar da ATP. ATP yana aiki a matsayin "man fetur" don ayyukan salula, yana ba da iko ga kowane bangare na rayuwa. Ba tare da isasshen NAD⁺ ba, samar da makamashin salula yana raguwa, yana haifar da raguwar kuzari da ƙarfin aiki gabaɗaya.
Bayan metabolism na makamashi, NAD⁺ yana taka muhimmiyar rawa a gyaran DNA da kwanciyar hankali. Kwayoyin suna fuskantar kullun ga lalacewar DNA daga abubuwan muhalli da abubuwan da ke haifar da rayuwa, kuma NAD⁺ yana kunna enzymes gyara don gyara waɗannan kurakurai. Har ila yau yana kunna sirtuins, dangin sunadaran da ke hade da tsawon rai, aikin mitochondrial, da ma'auni na rayuwa. Don haka, NAD⁺ ba makawa ba ne kawai don kiyaye lafiya amma kuma babban abin da ake mayar da hankali ne a cikin binciken rigakafin tsufa.
NAD⁺ yana da mahimmanci a cikin amsawa ga damuwa ta salula da kuma kare tsarin jin tsoro. Yayin damuwa na oxidative ko kumburi, NAD⁺ yana taimakawa daidaita siginar salula da ma'aunin ion don kula da homeostasis. A cikin tsarin jin tsoro, yana tallafawa lafiyar mitochondrial, yana rage lalacewar oxidative ga ƙwayoyin cuta, kuma yana taimakawa jinkirta farawa da ci gaba da cututtukan neurodegenerative.
Koyaya, matakan NAD a zahiri suna raguwa tare da shekaru. Wannan raguwa yana da alaƙa da raguwar samar da makamashi, rashin gyare-gyaren DNA, ƙara yawan kumburi, da raguwar ayyukan jijiyoyi, duk waɗannan alamun tsufa da cututtuka na yau da kullum. Tsayawa ko haɓaka matakan NAD⁺ don haka ya zama babban abin da ake mayar da hankali a cikin kula da lafiya na zamani da bincike na tsawon rai. Masana kimiyya suna binciko kari tare da magabatan NAD⁺ kamar NMN ko NR, da kuma matakan rayuwa, don ci gaba da matakan NAD⁺, haɓaka kuzari, da haɓaka lafiyar gabaɗaya.
Lokacin aikawa: Agusta-20-2025