Orlistat 96829-58-2 Rage Shayar da Fat ɗin Sietary, Sakamakon Rage Nauyi

Kayayyaki

Farin crystalline foda, kusan marar narkewa a cikin ruwa, sauƙi mai narkewa a cikin chloroform, musamman mai narkewa a cikin methanol da ethanol, mai sauƙin pyrolyze, wurin narkewa shine 40 ℃～42 ℃. Kwayoyinsa diastereomer ne mai dauke da cibiyoyi hudu na chiral, a tsawon 529nm, maganin ethanol ɗin sa yana da jujjuyawar gani mara kyau.

Yanayin Aiki

Orlistat wani dogon aiki ne kuma mai ƙayyadaddun ƙayyadaddun mai hana lipase na gastrointestinal fili, wanda ke hana enzymes biyu na sama ta hanyar samar da haɗin gwiwa tare da rukunin serine mai aiki na lipase a cikin ciki da ƙananan hanji. Enzymes da ba a kunna ba ba za su iya karya kitse a cikin abinci zuwa fatty acids kyauta da kuma glycerol na sinadarai wanda jiki zai iya sha, ta haka yana rage yawan kitse da rage kiba. Bugu da ƙari, wasu binciken sun gano cewa orlistat yana hana ƙwayar hanji na cholesterol ta hanyar hana niemann-pick C1-like protein 1 (niemann-pickC1-like1, NPC1L1).

Alamu

Wannan samfurin a hade tare da ƙarancin abinci na hypocaloric an nuna shi don dogon lokacin jiyya na masu kiba da masu kiba, gami da waɗanda ke da ingantattun abubuwan haɗari masu alaƙa da kiba. Wannan samfurin yana da ikon sarrafa nauyi na dogon lokaci (asara nauyi, kiyaye nauyi da rigakafin sake dawowa) inganci. Shan orlistat na iya rage abubuwan haɗari masu alaƙa da kiba da abubuwan da ke faruwa na wasu cututtukan da ke da alaƙa da kiba, gami da hypercholesterolemia, nau'in ciwon sukari na 2, rashin haƙuri na glucose, hyperinsulinemia, hauhawar jini, da rage yawan mai.

Ma'amalar Magunguna

Zai iya rage sha na bitamin A, D da E. Ana iya ƙarawa da wannan samfurin a lokaci guda. Idan kuna shan shirye-shirye dauke da bitamin A, D da E (kamar wasu multivitamins), yakamata ku ɗauki wannan samfurin sa'o'i 2 bayan shan wannan samfurin ko lokacin bacci. Mutanen da ke da nau'in ciwon sukari na 2 na iya buƙatar rage adadin magungunan hypoglycemic na baki (misali, sulfonylureas). Gudanar da haɗin gwiwa tare da cyclosporine na iya haifar da raguwa a cikin ƙwayoyin plasma na ƙarshen. Yin amfani da amiodarone a lokaci guda na iya haifar da raguwar sha na ƙarshen da rage tasiri.