Plozasiran

Plozasiran (API)

Aikace-aikacen Bincike:
Plozasiran API shine ƙaramin RNA (siRNA) na roba wanda aka haɓaka don maganin hypertriglyceridemia da cututtukan zuciya da jijiyoyin jini da ke da alaƙa. Yana kaiwa hariAPOC3Halitta, wanda ke ɓoye apolipoprotein C-III, mai mahimmanci mai kula da metabolism na triglyceride. A cikin bincike, ana amfani da Plozasiran don yin nazarin dabarun rage yawan lipid na tushen RNAi, ƙayyadaddun ƙayyadaddun kwayoyin halitta, da kuma dogon aiki na jiyya don yanayi irin su cututtukan chylomicronemia na iyali (FCS) da gauraye dyslipidemia.

Aiki:
Plozasiran yana aiki ta hanyar yin shiruAPOC3mRNA a cikin hanta, yana haifar da raguwa a matakan apolipoprotein C-III. Wannan yana haɓaka haɓakar lipolysis da kawar da lipoproteins masu wadatar triglyceride daga magudanar jini. A matsayin API, Plozasiran yana ba da damar haɓaka hanyoyin kwantar da hankali na dogon lokaci da nufin rage yawan matakan triglyceride da rage haɗarin cututtukan pancreatitis da cututtukan zuciya a cikin marasa lafiya da cututtukan lipid mai tsanani ko ƙwayoyin cuta.