Kayayyaki
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Givosiran
Givosiran API wani ƙaramin RNA ne mai shiga tsakani (siRNA) wanda aka yi nazari don maganin cututtukan hanta mai tsanani (AHP). Yana musamman hari daALAS1gene (aminolevulinic acid synthase 1), wanda ke da hannu a cikin hanyar heme biosynthesis. Masu bincike suna amfani da Givosiran don yin bincike kan tsoma bakin RNA (RNAi), hanyoyin kwantar da hankali na hanta da ke da niyya, da daidaita hanyoyin hanyoyin rayuwa da ke cikin porphyria da cututtukan ƙwayoyin cuta masu alaƙa.
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Pegcetacoplan
Pegcetacoplan peptide ne na cyclic pegylated wanda ke aiki azaman mai hanawa C3 da aka yi niyya, wanda aka haɓaka don maganin cututtukan da aka haɗa da su kamar paroxysmal nocturnal hemoglobinuria (PNH) da atrophy geographic (GA) a cikin macular degeneration shekaru.
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Plozasiran
Plozasiran API shine ƙaramin RNA (siRNA) na roba wanda aka haɓaka don maganin hypertriglyceridemia da cututtukan zuciya da jijiyoyin jini da ke da alaƙa. Yana kaiwa hariAPOC3Halitta, wanda ke ɓoye apolipoprotein C-III, mai mahimmanci mai kula da metabolism na triglyceride. A cikin bincike, ana amfani da Plozasiran don yin nazarin dabarun rage yawan lipid na tushen RNAi, ƙayyadaddun ƙayyadaddun kwayoyin halitta, da kuma dogon aiki na jiyya don yanayi irin su cututtukan chylomicronemia na iyali (FCS) da gauraye dyslipidemia.
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Zilebesiran
Zilebesiran API ƙaramin bincike ne na RNA (siRNA) wanda aka haɓaka don maganin hauhawar jini. Yana kaiwa hariAGTgene, wanda ke ɓoye angiotensinogen-wani maɓalli mai mahimmanci na tsarin renin-angiotensin-aldosterone (RAAS). A cikin bincike, ana amfani da Zilebesiran don nazarin hanyoyin yin shiru na kwayoyin halitta don sarrafa hawan jini na dogon lokaci, fasahar isar da RNAi, da kuma faffadan rawar hanyar RAAS a cikin cututtukan zuciya da na koda.
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Palopegteriparatide
Palopegteriparatide wani agonist mai karɓa na hormone na parathyroid mai tsawo (PTH1R agonist), wanda aka haɓaka don maganin hypoparathyroidism na kullum. Yana da pegylated analog na PTH (1-34) wanda aka ƙera don samar da dorewar ƙa'idar calcium tare da allurai sau ɗaya a mako.
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GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) wani hexapeptide na roba ne wanda ke aiki a matsayin secretagogue na hormone girma, yana motsa jikin jiki na sakin hormone girma (GH) ta hanyar kunna mai karɓar GHSR-1a.
Abubuwan API:
Tsafta ≥99%
Kerarre ta hanyar Solid-lokaci peptide synthesis (SPPS)
An ba da shi don R&D da amfanin kasuwanci
GHRP-6 shine peptide bincike mai mahimmanci don goyon bayan rayuwa, farfadowa na tsoka, da daidaitawar hormonal.
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GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) wani hexapeptide na roba ne da kuma sirrin haɓakar haɓakar hormone mai ƙarfi, wanda aka tsara don tada yanayin sakin hormone girma (GH) ta hanyar kunna mai karɓar GHSR-1a a cikin hypothalamus da pituitary.
Abubuwan API:
Tsafta ≥99%
Akwai don R&D da wadatar kasuwanci, tare da cikakkun takaddun QC
GHRP-2 peptide bincike ne mai mahimmanci a fagen ilimin endocrinology, magani mai sabuntawa, da hanyoyin kwantar da hankali na shekaru.
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Hexarelin
Hexarelin shine peptide peptide hormone girma na roba (GHS) da kuma GHSR-1a agonist mai ƙarfi, wanda aka haɓaka don haɓaka haɓakar haɓakar hormone (GH). Yana cikin dangin ghrelin mimetic kuma ya ƙunshi amino acid shida (wani hexapeptide), yana ba da ingantaccen kwanciyar hankali na rayuwa da ƙarin tasirin sakin GH idan aka kwatanta da analogs na baya kamar GHRP-6.
Abubuwan API:
Tsafta ≥ 99%
Ana samarwa ta hanyar haɗakar peptide mai ƙarfi (SPPS)
Matsayi kamar GMP, ƙarancin endotoxin da ragowar sauran ƙarfi
Samfura mai sassauƙa: R&D zuwa sikelin kasuwanci
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Melanotan II
Abubuwan API:
Babban tsarki ≥ 99%
Haɗa ta hanyar haɗakar peptide mai ƙarfi-lokaci (SPPS)
Low endotoxin, ƙananan sauran kaushi
Akwai a cikin R&D zuwa sikelin kasuwanci -
Melanotan 1
Ana samar da Melanotan 1 API ta amfani da fasaha mai ƙarfi peptide synthesis (SPPS) a ƙarƙashin tsauraran yanayin sarrafa ingancin GMP.
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Babban tsarki ≥99%
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Haɗin peptide mai ƙarfi (SPPS)
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Matsayin masana'anta kamar GMP
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Cikakken takaddun: COA, MSDS, bayanan kwanciyar hankali
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Samar da ƙima: R&D zuwa matakan kasuwanci
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MOTS-C
MOTS-C API an samar da shi a ƙarƙashin tsauraran yanayin GMP-kamar ta amfani da fasaha mai ƙarfi peptide kira (SPPS) don tabbatar da ingancinsa mai girma, babban tsabta da kwanciyar hankali don bincike da amfani da warkewa.
Siffofin samfur:Tsafta ≥ 99% (HPLC da LC-MS sun tabbatar),
Low endotoxin da sauran sauran ƙarfi abun ciki,
An samar da shi daidai da ICH Q7 da ka'idojin GMP,
Za a iya cimma babban samarwa, daga matakin miligram-R&D batches zuwa matakin-gram da wadatar kasuwancin kilogiram. -
Ipamorelin
Ipamorelin API an shirya shi ta hanyar babban tsari ** m lokaci peptide synthesis process (SPPS)** kuma yana fuskantar tsattsauran tsarkakewa da gwajin inganci, wanda ya dace da fara amfani da bututun mai a cikin binciken kimiyya da haɓakawa da kamfanonin harhada magunguna.
Siffofin samfur sun haɗa da:
Tsafta ≥99% (gwajin HPLC)
Babu endotoxin, ƙarancin sauran ƙarfi, ƙarancin ƙarancin ƙarfe ion
Samar da cikakken saitin ingantattun takardu: COA, rahoton nazarin kwanciyar hankali, nazarin bakan ƙazanta, da sauransu.
Matsakaicin wadatar matakin-gram~kilogram