Sildenafil Citrate Maganin Rashin Matsala 171599-83-0
Cikakken Bayani
| Suna | Sildenafil Citrate |
| Lambar CAS | 171599-83-0 |
| Tsarin kwayoyin halitta | Saukewa: C28H38N6O11S |
| Nauyin kwayoyin halitta | 666.70 |
| Lambar EINECS | 200-659-6 |
| Merck | 14,8489 |
| Yawan yawa | 1.445g/cm 3 |
| Yanayin ajiya | 2-8 ° C |
| Siffar | Foda |
| Launi | Fari |
| Ruwa mai narkewa | DMSO:> 20mg/ml |
Makamantu
Viagra, Sildenafil citrate; 1-[3- (4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazinecitratesalt; 5-[2-Ethoxy-5- (4-methylpiperazin-1-yl) sulfonylphenyl] -1-methyl-3-propyl-4H-pyrazolo [5,4-e] pyrimidin-7-onecitratesalt; 1-[3- (6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl] sulfonyl] -4-methylpiperazine,2-hydroxy-1,2,3-propanetricarboxylate; SildenafilCitrate (100 MG); Sildenafilcitrate,>=99%;Sildenafilcitrate,Sarrafawa; 5-[2-Ethoxy-5-[(4-methyl-piperazin-1-yl) sulfonyl] phenyl] -1,6-dihydro-1-methyl-3-propyl-7H-pyrazolo [4,3-d] pyrimidin-7-onecitrate
Tasirin Magunguna
Ayyukan Pharmacological
Sildenafil citrate wani zaɓi ne na 5-phosphodiesterase inhibitor wanda ke haɓaka nitric oxide-dependent, cyclic guanosine monophosphate-mediated pulmonary vasodilation ta hanyar hana rushewar cyclic guanosine monophosphate. Baya ga faɗaɗa kai tsaye na tasoshin jini na huhu, kuma yana iya hana ko juyar da gyare-gyaren jijiyoyin jini.
Abubuwan Magunguna da Aikace-aikace
Sildenafil citrate, sunan kasuwanci Viagre, wanda aka fi sani da Viagra, shine cyclic guanosine monophosphate (cGMP) - takamaiman nau'in phosphodiesterase 5 (PDE5) mai hanawa wanda zai iya haɓaka haɓakawa bayan gudanarwa ta baki. Sildenafil citrate zai iya inganta tasirin nitric oxide (NO) ta hanyar hana nau'in 5 phosphodiesterase wanda ke lalata cyclic guanosine monophosphate (cGMP) a cikin corpus cavernosum. Ƙara matakin cGMP a cikin corpus cavernosum, shakata da santsin tsoka a cikin corpus cavernosum, ƙara yawan jini, tsawaita lokacin tsawan azzakari da ƙara ƙarfi. Ga marasa lafiya da rashin aikin yi. Manya suna shan 50 MG na baki kowane lokaci, har zuwa sau 1 a rana, kuma suna amfani da shi kamar yadda ake bukata kamar awa 1 kafin jima'i. Matsakaicin adadin shine 0.1g kowane lokaci.
A cikin karatun vivo
A cikin karnuka masu anesthetized, Sildenafil citrate yana haɓaka aikin penile erectile a ƙarƙashin ƙwayar jijiyar ƙwanƙwasa ta hanyar auna matsa lamba intracavernous. Sildenafil citrate da alama yana jujjuya raunin carbamoylcholine-ƙarfafa shakatawa da hana samuwar superoxide a cikin ƙwayar cavernosal na zomaye hypercholesterolemic. A cikin ratsan Sprague-Dawley, Sildenafil yana inganta aikin haɓakawa a cikin hanyar da ta dace da lokaci-lokaci, tare da mafi girman farfadowa da ke faruwa a ranar 28 a kashi na 20 mg / kg kowace rana. A cikin berayen Sprague-Dawley, gudanar da Sildenafil ya haifar da adana ƙwayar ƙwayar tsoka mai santsi da adana CD31 da maganganun eNOS. A cikin ratsan Sprague-Dawley, Sildenafil ya rage mahimmancin alamar apoptotic kuma ya karu da phosphorylation na akt da eNOS idan aka kwatanta da ƙungiyar kulawa.
