Tadalafil 171596-29-5 don Magance Rashin Matsala a Maza

Tadalafil (Tadalafil, Tadalafil) yana da tsarin kwayoyin halitta na C22H19N3O4 da nauyin kwayoyin halitta na 389.4. An yi amfani da ita sosai wajen magance tabarbarewar mazakuta tun 2003, tare da sunan kasuwanci Cialis (Cialis). A cikin Yuni 2009, FDA ta amince da tadalafil a Amurka don kula da marasa lafiya tare da hauhawar jini na huhu (PAH) a ƙarƙashin sunan kasuwanci Adcirca. An gabatar da Tadalafil a cikin 2003 a matsayin magani don maganin ED. Yana aiki bayan mintuna 30 bayan gudanarwa, amma mafi kyawun tasirinsa shine 2h bayan fara aikin, kuma tasirin zai iya ɗaukar awanni 36, kuma tasirinsa ba ya shafar abinci. Matsakaicin tadalafil shine 10 ko 20 MG, shawarar farko da aka ba da shawarar shine 10 MG, kuma ana daidaita kashi bisa ga amsawar mai haƙuri da halayen mara kyau. Nazarin kafin kasuwa ya nuna cewa bayan gudanar da baki na 10 ko 20 MG na tadalafil don makonni 12, ƙimar tasiri shine 67% da 81%, bi da bi. Yawancin karatu sun nuna cewa tadalafil yana da tasiri mafi kyau a cikin maganin ED.

Rashin Ciwon Ciki: Tadalafil wani zaɓi ne na nau'in phosphodiesterase 5 (PDE5) kamar sildenafil, amma tsarinsa ya bambanta da na ƙarshe, kuma abincin mai mai yawa ba ya tsoma baki tare da sha. A karkashin aikin motsa jiki na jima'i, nitric oxide synthase (NOS) a cikin ƙananan jijiyar penile da sel endothelial na jijiyoyi suna haifar da kira na nitric oxide (NO) daga substrate L-arginine. NO yana kunna guanylate cyclase, wanda ke canza guanosine triphosphate zuwa cyclic guanosine monophosphate (cGMP), don haka kunna cyclic guanosine monophosphate-dependent protein kinase, wanda ya haifar da raguwa a cikin maida hankali na ions na calcium a cikin ƙwayoyin tsoka mai santsi, haifar da cavernosum na corpus cavernosum Erection yana faruwa saboda shakatawa na tsoka mai santsi. Nau'in phosphodiesterase 5 (PDE5) yana ƙasƙantar da cGMP zuwa samfuran marasa aiki, yana mai da azzakari cikin yanayin rauni. Tadalafil yana hana lalatawar PDE5, yana haifar da tarawar cGMP, wanda ke kwantar da tsoka mai laushi na corpus cavernosum, yana haifar da haɓakar penile. Tun da nitrates ba masu ba da gudummawa ba ne, haɗuwa da amfani tare da tadalafil zai ƙara yawan matakin cGMP kuma ya haifar da rashin ƙarfi mai tsanani. Sabili da haka, haɗuwa da amfani da su biyu an hana su a cikin aikin asibiti.

Tadalafil yana aiki ta hanyar hana PDES. GMP ya lalace, don haka hada amfani da nitrates na iya haifar da matsananciyar faɗuwar hawan jini kuma yana ƙara haɗarin syncope. CY3PA4 inducers za su rage bioavailability na tadanafil, da kuma hade tare da rifampicin, cimetidine, erythromycin, clarithromycin, itracon, ketocon, da HVI protease inhibitors na iya kara yawan jini na miyagun ƙwayoyi ya kamata a gyara. Ya zuwa yanzu, babu rahotanni cewa sigogi na pharmacokinetic na wannan samfurin suna shafar abinci da barasa.