Vardenafil Dihydrochlloricide bi da orectila dysfunction na shekara 224785-5-5

Mataki na magunguna
Wannan magani shine nau'in phosphodiestrasy 5 (PDE5) inhibitor. Maganar baka na wannan magani na iya inganta inganci da tsawon lokaci na rashin tsari, kuma inganta raunin rayuwar jima'i a cikin marasa lafiya na maza tare da dysfunction. Qaddamarwa da kiyaye erection enile yana da alaƙa da annashuwa na ƙwayoyin tsoka mai laushi, kuma matsakanci) matsakanci ne na sel tsoka. Wannan magani yana hana bazuwar cgmp ta hanyar inbhiastate nau'in phosphodiestrate na CGPUSHODOSUM, da kuma rashin daidaituwa na azzakari. Idan aka kwatanta da phosphodiestate isozymes 1, 2, 3, 4, da 4, wannan magani yana da zaɓi 5 na phosphodiestatevery. Wasu bayanan suna nuna cewa Zabi da Zabi da Tasirin inhibitory akan nau'in phosphodiestrasate 5 sun fi sauran nau'in phosphodiestrasy 5 masu hana. Rubuta phosphodiestoreors few.

Magunguna da aikace-aikace

1. Lokacin da aka yi amfani da shi tare da Cyp 3a4 (kamar Ritonavir, Indovole, Erconiavir, tsara da rabin-rai, da kuma ƙara fitowar rabin rai, kamar yadda ake ciki, gani Canje-canje, ciwon kai, fuska ta flushing, praipism). Ya kamata a guji wannan magani a hade tare da ritonavir da Indinavir. Lokacin amfani dashi a hade tare da Erythromycincin, ketconzoole, da Itolonoazole, matsakaicin wannan miyagun wannan magani bai kamata ya wuce 5 MG ba.
2. Marasa lafiya suna ɗaukar nitrates ko karɓar nitric oitric operpy don hana amfani da wannan magani a hade. Hanyarsa ta aiwatarwa ita ce kara karuwa daTaro na CGPM, wanda ya haifar da inganta ingantaccen sakamako da kuma ƙara yawan zuciya. A lokacin da aka yi amfani da shi tare da blockers α-mai karbar karye, zai iya inganta tasirin enihypertalista da kai ga hypotinsion. Sabili da haka, yin amfani da wannan magani an haramta wa waɗanda suke amfani da masu rikodin α-regvorror. Abincin mai-matsakaici-mai (30% na adadin kuzari na mai) ba shi da tasiri a kan Pharacharacharacharancin wannan magani, da kuma rage yawan kitse na wannan magani da yake kusan 18%.

Pharpacak
Ana ɗaukar nauyin hanzari cikin sauri, ingantacciyar ra'ayi na kwamfutar hannu na baki shine 15%, kuma matsakaita lokacin ganiya shine 1h (0.5-2h). Magani na baka 10MG ko 20mg, matsakaicin lokacin ganyayyaki shine 0.9h, matsin lamba peak plasma shine 9.7h, bi da amsar m, da kuma tsawon lokacin sakamako na iya kaiwa 1H. Matsakaicin nauyin wannan magani shine kusan 95%. 1.5h bayan wani yanki na baka guda na 20 mg, da abun ciki abun ciki a cikin maniyyin shine 0.00018% na kashi. A miyagun ƙwayoyi ne galibi a hanta ta cynochrome P450 (Cyp) 3a4, kuma Cyp 2C9 Isoenzymes. Babban metabolite shine M1 wanda aka kafa ta hanyar Deethylation na bututun mai game da wannan magani. M1 Hakanan yana da tasirin hanawa phooshisiestrasetore 5 (kimanin 7% na jimlar kai na kusan 26% na taro jini jini jini ne na iyayen jini. , kuma ana iya ci gaba da metabolized. Resultarwar magunguna a cikin nau'in metabolites a cikin feces da fitsari kusan 91% zuwa 65% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6% zuwa 6%. Matsakaicin tsararraki shine 56 Lther na awa daya, da rabin rayuwar mahaifa da M1 sun kasance kusan 4 zuwa 5 hours.