Zilebesiran

Zilebesiran (API)

Aikace-aikacen Bincike:
Zilebesiran API ƙaramin bincike ne na RNA (siRNA) wanda aka haɓaka don maganin hauhawar jini. Yana kaiwa hariAGTgene, wanda ke ɓoye angiotensinogen-wani maɓalli mai mahimmanci na tsarin renin-angiotensin-aldosterone (RAAS). A cikin bincike, ana amfani da Zilebesiran don nazarin hanyoyin yin shiru na kwayoyin halitta don sarrafa hawan jini na dogon lokaci, fasahar isar da RNAi, da kuma faffadan rawar hanyar RAAS a cikin cututtukan zuciya da na koda.

Aiki:
Zilebesiran yana aiki ta hanyar yin shiruAGTmRNA a cikin hanta, yana haifar da raguwar samar da angiotensinogen. Wannan yana haifar da raguwa a cikin matakan angiotensin II, yana taimakawa wajen rage karfin jini a cikin tsari mai dorewa. A matsayin API, Zilebesiran yana ba da damar haɓaka ayyukan dogon aiki, hanyoyin kwantar da hankali na subcutaneous tare da yuwuwar yin allurai na kwata ko na shekara-shekara, yana ba da ingantaccen riko da sarrafa hawan jini.