Carbetocin don Hana Ciwon Uterine da Jini na Bayan Haihuwa
Cikakken Bayani
| Suna | KARBETOCI |
| Lambar CAS | 37025-55-1 |
| Tsarin kwayoyin halitta | Saukewa: C45H69N11O12S |
| Nauyin kwayoyin halitta | 988.17 |
| Lambar EINECS | 253-312-6 |
| Takamaiman juyawa | D -69.0° (c = 0.25 a cikin 1M acetic acid) |
| Wurin tafasa | 1477.9 ± 65.0 °C (An annabta) |
| Yawan yawa | 1.218± 0.06 g/cm3 (An annabta) |
| Yanayin ajiya | -15°C |
| Siffar | foda |
Makamantu
BUTYRYL-TYR(ME) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME) -ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; KARBETOCI; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Ayyukan halittu
Carbetocin, analog na oxytocin (OT), shine agonist mai karɓa na oxytocin tare da Ki na 7.1 nM. Carbetocin yana da alaƙa mai girma (Ki = 1.17 μM) don ƙirar N-terminus na mai karɓar oxytocin. Carbetocin yana da yuwuwar yin bincike game da zubar jini bayan haihuwa. Carbetocin na iya shiga shingen kwakwalwar jini kuma yana da aikin antidepressant ta hanyar kunna masu karɓar oxytocin a cikin CNS.
Aiki
Carbetocin shine analog na oxytocin 8-peptide na roba na roba mai tsayi tare da kaddarorin agonist, kuma kayan aikin sa na asibiti da na likitanci sun yi kama da na oxytocin da ke faruwa a zahiri. Kamar oxytocin, carbetocin yana ɗaure ga masu karɓar hormone na ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar jiki. Matakan masu karɓa na Oxytocin a cikin mahaifa suna da ƙasa a cikin yanayin marasa ciki, karuwa a lokacin daukar ciki, da kuma mafi girma a lokacin aiki. Saboda haka, carbetocin ba shi da wani tasiri a kan mahaifar da ba mai ciki ba, amma yana da tasiri mai tasiri a kan mahaifa mai ciki da kuma sabon mahaifa.
Canja Gudanarwa
Ana sarrafa canje-canje bisa ga hanya. Dangane da tasiri da haɗari da tsanani, ana rarraba canje-canje a matsayin Manyan, Ƙarami da Site. Canje-canjen rukunin yanar gizon suna da ɗan tasiri akan aminci da ingancin samfur, sabili da haka baya buƙatar amincewa da sanarwa ga abokin ciniki; Ƙananan canje-canje suna da matsakaicin tasiri akan aminci da ingancin samfur, kuma suna buƙatar sanar da abokin ciniki; Manyan canje-canje suna da babban tasiri akan aminci da ingancin samfur, kuma suna buƙatar amincewa ta abokin ciniki.
Dangane da hanyar, ana fara sarrafa canji tare da aikace-aikacen canji wanda aka bayyana cikakkun bayanai da ma'ana don canjin. Ana aiwatar da kimantawa ta bin aikace-aikacen, wanda aka yi ta hanyar canjin iko da sassan da suka dace. A halin yanzu, ana rarraba sarrafa canjin zuwa Babban matakin, Babban matakin da ƙarami. Bayan kimanta da ya dace da kuma rarrabuwa, duk sarrafa canjin matakin ya kamata a amince da shi ta Manajan QA. Ana aiwatar da sarrafa canjin bayan amincewa bisa ga tsarin aiki. A ƙarshe an rufe sarrafa canjin bayan QA ya tabbatar da aiwatar da sarrafa canjin yadda ya kamata. Idan ya haɗa da sanarwar abokin ciniki, ya kamata a sanar da abokin ciniki akan lokaci bayan an amince da canjin canji
