Atosiban Acetate da ake amfani da shi don Haihuwar Haihuwa
Cikakken Bayani
| Suna | Atosiban |
| Lambar CAS | 90779-69-4 |
| Tsarin kwayoyin halitta | Saukewa: C43H67N11O12S2 |
| Nauyin kwayoyin halitta | 994.19 |
| Lambar EINECS | 806-815-5 |
| Wurin tafasa | 1469.0 ± 65.0 °C (An annabta) |
| Yawan yawa | 1.254± 0.06 g/cm3 (An annabta) |
| Yanayin ajiya | -20°C |
| Solubility | H2O: ≤100 mg/ml |
Bayani
Atosiban acetate shine polypeptide na cyclic na disulfide wanda ya ƙunshi amino acid 9.Yana da kwayoyin oxytocin da aka gyara a matsayi na 1, 2, 4 da 8. N-terminus na peptide shine 3-mercaptopropionic acid (thiol da Sulfhydryl group na [Cys] 6 yana samar da haɗin disulfide), C-terminal shine. a cikin sigar amide, amino acid na biyu a N-terminal shine ethylated modified [D-Tyr (Et)] 2, kuma ana amfani da atosiban acetate a cikin magunguna azaman vinegar Yana wanzuwa a cikin hanyar gishirin acid, yawanci. da aka sani da atosiban acetate.
Aikace-aikace
Atosiban shine oxytocin da vasopressin V1A hade da antagonist mai karɓa, mai karɓa na oxytocin yana da tsari mai kama da mai karɓa na vasopressin V1A.Lokacin da aka toshe mai karɓar oxytocin, oxytocin na iya yin aiki ta hanyar mai karɓar V1A, don haka ya zama dole a toshe hanyoyin masu karɓa guda biyu na sama a lokaci guda, kuma ƙin yarda guda ɗaya na mai karɓa ɗaya zai iya hana ƙwayar mahaifa ta yadda ya kamata.Wannan kuma shine ɗayan manyan dalilan da ya sa agonists β-receptor, masu hana tashar calcium da masu hana prostaglandin synthase ba za su iya hana haɓakar mahaifa ba yadda ya kamata.
Tasiri
Atosiban shine haɗe-haɗe antagonist na oxytocin da vasopressin V1A, tsarin sinadaransa yayi kama da biyun, kuma yana da alaƙa mai girma ga masu karɓa, kuma yana gasa tare da oxytocin da vasopressin V1A receptors, ta haka ne ya toshe hanyar aiki na oxytocin da vasopressin da ragewa. kumburin mahaifa.
