Eptifibatide don Maganin Cutar Cutar Cutar Kwalara 188627-80-7
Cikakken Bayani
| Suna | Eptifibatide |
| Lambar CAS | 188627-80-7 |
| Tsarin kwayoyin halitta | Saukewa: C35H49N11O9S2 |
| Nauyin kwayoyin halitta | 831.96 |
| Lambar EINECS | 641-366-7 |
| Yawan yawa | 1.60± 0.1 g/cm3 (An annabta) |
| Yanayin ajiya | An rufe shi a bushe, adana a cikin injin daskarewa, ƙasa da -15 ° C |
Makamantu
Eptifibatideacetatesalt;Eptifibatide,MPA-HAR-Gly-Asp-Trp-Pro-Cys-NH2,MPAHARGDWPC-NH2,>99%;MAP-LYS-GLY-ASP-TRP-PRO-CYS-NH2;INTEGRELIN;Eptifibatide; (Aminoiminomethyl) -N2- (3-mercapto-1-oxopropyl-L-lysylglycyl-La-aspartyl-L-tryptophyl-L-prolyl-L-cysteinamide;MPA-HAR-GLY-ASP-TRP-PRO-CYS-NH2 (DISULFIDEBRIDGE,MPA1-CYS6).
Platelet Glycoprotein antagonist
Etifibatide (integrilin) wani labari ne na polypeptide platelet glycoprotein IIb/IIIa antagonist mai karɓa, wanda ke hana haɗuwar platelet da thrombosis ta hanyar hana hanyar gama gari ta ƙarshe ta tara platelet.Idan aka kwatanta da monoclonal antibody abciximab, eptifibatide yana da ƙarfi, ƙarin jagora da ƙayyadaddun ɗauri ga GPIIb/IIIa saboda kasancewar amino acid mai ra'ayin mazan jiya guda ɗaya-lysine don maye gurbin arginine.Sabili da haka, ya kamata ya sami sakamako mai kyau na warkewa a cikin maganin sa baki na ciwo mai tsanani.Platelet glycoprotein IIb/IIIa receptor antagonist kwayoyi an haɓaka su da yawa, kuma a halin yanzu akwai nau'ikan shirye-shirye guda 3 waɗanda za a iya amfani da su a cikin asibiti na duniya, abciximab, eptifibatide da tirofiban.).Akwai ƙarancin gogewa game da amfani da platelet glycoprotein GPIIb/IIIa antagonists receptor antagonists a China, kuma akwai magunguna ma suna da iyaka.Magunguna guda ɗaya, tirofiban hydrochloride, yana kasuwa.Don haka, an haɓaka sabon platelet glycoprotein IIb./IIIa antagonists masu karɓa suna da mahimmanci.Eptifibatide na cikin gida samfurin kwaikwayo ne na Chengdu Sino Biological Products Co., Ltd.
Rabewa
Rarraba Magungunan Haɗin Antiplatelet
Ana iya raba magungunan antiplatelet kusan kashi uku: 1. Cyclooxygenase-1 (COX-1) masu hanawa, kamar aspirin.2. Hana haɗin platelet wanda adenosine diphosphate (ADP) ya haifar da su, irin su clopidogrel, prasugrel, cangrelor, ticagrelor, da dai sauransu. prostaglandin EP3 receptor inhibitors, sabon hada sinadaran sinadaran da kuma tasiri tsantsa daga gargajiya na kasar Sin.
