Terlipressin Acetate na Esophageal Variceal Bleeding

Terlipressin, wanda sunansa sunansa shine triglycyllysine vasopressin, sabon shiri ne na vasopressin na roba.Wani nau'in prodrug ne, wanda baya aiki da kansa.Aminopeptidase ne ke yin shi a cikin vivo don a hankali "saki" lysine vasopressin mai aiki bayan cire ragowar glycyl guda uku a N-terminus.Saboda haka, terlipressin yana aiki a matsayin tafki wanda ke sakin lysine vasopressin a daidai gwargwado.

Sakamakon pharmacological na terlipressin shine ƙaddamar da ƙwayar tsoka mai santsi mai santsi da kuma rage zubar jini na splanchnic (kamar rage yawan jini a cikin mesentery, splin, mahaifa, da dai sauransu), don haka rage yawan jini na portal da kuma matsa lamba.A gefe guda kuma, yana iya rage ƙwayar plasma Tasirin maida hankali na renin, don haka ƙara yawan jini na koda, inganta aikin koda da kuma ƙara yawan fitsari a cikin marasa lafiya da ciwon hepatorenal.Terlipressin a halin yanzu shine kawai magani wanda zai iya inganta yawan rayuwa na marasa lafiya tare da zubar da jini na esophageal variceal.An yi amfani da shi musamman wajen maganin ciwon jini na variceal.Bugu da ƙari, an yi amfani da terlipressin cikin nasara a cikin hanta da koda.Gabaɗaya, yana yiwuwa ya taka rawa mai fa'ida wajen kasancewa tare da girgizawa da tashin hankali na zuciya.Idan aka kwatanta da vasopressin, yana da tasiri mai dorewa, baya haifar da rikitarwa masu haɗari, ciki har da fibrinolysis da rikitarwa mai tsanani a cikin tsarin zuciya da jijiyoyin jini, kuma yana da sauƙin amfani (alurar rigakafi), wanda ya fi dacewa da kulawa mai mahimmanci da mahimmanci.Ceto da kula da majinyata marasa lafiya.