Caspofucnd don cututtukan dabbobi
Cikakken Bayani
| Suna | Caspofunkgin |
| Lambar CAS | 162808-62-0 |
| Tsarin kwayoyin halitta | C52H888N10O15 |
| Nauyi na kwayoyin | 1093.31 |
| Lambar Einecs | 1806241-261-263-5 |
| Tafasa | 1408.1 ± 65.0 ° C (annabta) |
| Yawa | 1.36 ± 0.1 g / cm3 (annabta) |
| Acidarancin acid | (Pka) 9.86 ± 0.26 (annabta) |
Kwatanci
Cs-117; caspofungine; caspofunkin; casporfunkin; pnaporfinginb0,1 - [(4-aminethyl) Amino] -5 - (10,12-Dimimetl -1-oxotetrownl) -4-hydroxy-l-ornithine] -5 - (3r) -3 -3 -3 -3 -3 -3 -3 -3 -3 -3; agaji; agaji-0586
Kayan sunadarai
Caspofar shi ne farkon ECHINOCANDINDIND don magance cututtukan fungal. A cikin vitro kuma a cikin gwaje-gwajen VIVO sun tabbatar da cewa Caspofurd yana da ayyukan ƙwallon ƙwayoyin rigakafin ƙwayoyin cuta game da mahimman dama-Cigida da Aspergillus. Caspofurgin zai iya lalata bangon tantanin halitta ta hanyar hanzarta tsarin kira na 1,3-β-Glucan. A asibiti, Caspofunkus yana da tasiri mai kyau game da lura da daban-daban cendiasis da aspergillero.
Sakamako
(1,3) -d-Glecan Synthase shine maɓalli na bangaren bango na fungal synthesis, da Caspoofurgin na iya yin tasiri mai tasirin antifiungal ta hanyar hana wannan enzyme. Bayan gwamnatin da ke haifar da cigaba, da plasma plasma maida hankali saukad da sauri saboda rarraba nama, mai zuwa ta hanyar maye gurbin magani daga nama. Metabolism of caspofungin increased with increasing dose and was dose-related in the time to steady state with multiple doses. Sabili da haka, don cimma ingantattun matakan warkewa kuma ku guji tara magani, ya kamata a gudanar da kashi na farko na farawa. When using cytochrome p4503A4 inducers at the same time, such as rifampicin, carbamazepine, dexamethasone, phenytoin, etc., it is recommended to increase the maintenance dose of caspofungin.
Alamar
Alamar amincewar FDA ta tabbatar da ita ta hada da: 1. Zazzabi> ≤500 / ml, ko kuma an yi hasashen cewa ana iya raguwa zuwa kasa da 500 / ml. Dangane da shawarar da cutar cututtukan Amurka (Idsa), duk da har yanzu marasa lafiya da ke da matukar rauni, ciki har da caspofucend da sauran magungunan da suka dace da magunguna. . 2. Candlive Candliesis: Idsa ta bada shawarar ECHINOCADINS (kamar Caspofucens (kamar Caspofucunky) Kamar yadda Magungunan Zabi don Casedimia. Hakanan za'a iya amfani dashi don magance cutar na ciki, peritonitis da cututtukan kirji wanda aka haifar daga cututtukan Candida. 3. Za'a iya amfani da alamu na esophageal Karatun da yawa sun gano cewa maganin warkewa na caspofugin yana daidai da cewa na Flucoyozole. 4. A aspergillis: An yarda da Caspofurgin: Caspofurgin an yarda da shi don lura da m magani, juriya, da rashin ingancin babban magani, Voriconizole. Koyaya, Echinocodin ba a ba da shawarar matsayin maganin farko ba.
