Chondroitin Sulfate don Maganin Ciwon Zuciya, Arthritis da Warkar da Raunin Corneal Tsabta 98%
Cikakken Bayani
| Suna | Chondroitin sulfate |
| Lambar CAS | 9007-28-7 |
| Tsarin kwayoyin halitta | Saukewa: C13H21NO15S |
| Nauyin kwayoyin halitta | 463.36854 |
| Lambar EINECS | 232-696-9 |
| Ruwa mai narkewa | Mai narkewa cikin ruwa |
| Tsafta | 98% |
| Adana | Adana a zazzabi na yau da kullun |
| Siffar | Foda |
| Launi | Fari zuwa farar fata |
| Shiryawa | PE bag+Aluminum bag |
Makamantu
poly-1 (2/3) -n-acetyl-2-amino-2-deoxy-3-o-beta-d-glucopyranurosyl-4- (6) sulfonyl-d-galactose;chondroitinpoly sulfate;chondroitin sulfates;chondroiti nsulfuric acid;chondroitin sulfuric acid;chonsurid;CSO; (5ξ) -2-(Carboxyamino) -2-deoxy-3-O-β-D-glucopyranuronosyl-4-O-sulfo-α-L-arabino-hexopyranose
Tasirin Magunguna
Bayani
Chondroitinsulfate (CS) shine mucopolysaccharide acidic wanda aka fitar kuma an tsarkake shi daga nama na guringuntsi na dabba.Chondroitin sulfate yana da nau'i daban-daban irin su A, C, D, E, H da K. Chondroitin sulfate a cikin yanayi yana samuwa a cikin guringuntsi na dabba, kashi makogwaro, kashi na hanci (41% a cikin alade), bovine, septum doki da trachea (wanda ya ƙunshi). 36% zuwa 39%), wasu nama kamar ƙasusuwan ƙafafu, ligaments, fata, cornea, da sauransu kuma suna ɗauke da su.Abin da ke cikin guringuntsin kifin yana da wadata sosai, kamar kashi 50 zuwa 60% a cikin kashi na shark, kuma kaɗan ne a cikin nama mai haɗawa.
Don cututtukan zuciya na atherosclerotic, ƙara yawan lipids na jini da cholesterol, arteriosclerosis, angina pectoris, ischemia myocardial ischemia, ciwon zuciya na zuciya, da dai sauransu a cikin marasa lafiya da cututtukan zuciya.
Ayyukan Pharmacological
Rapamycin (RAPA) yana da irin illar illa ga FK506.A cikin adadi mai yawa na gwaje-gwaje na asibiti, an gano abubuwan da ke tattare da shi sun kasance masu dogara da kashi-kashi da kuma sake dawowa, kuma RAPA a maganin warkewa ba a samo shi da mahimmancin nephrotoxicity kuma babu hyperplasia gingival.Babban mai guba da illa sun haɗa da: ciwon kai, tashin zuciya, juwa, zubar da hanci, da ciwon haɗin gwiwa.Laboratory abnormalities sun hada da: thrombocytopenia, leukopenia, low haemoglobin, hypertriglyceridemia, hypercholesterolemia, hyperglycemia, dagagge hanta enzymes (SGOT, SGPT), dagagge lactate dehydrogenase, hypokalemia, Hypomagnesemia, da dai sauransu. Eyelid edema da aka ruwaito kwanan nan tare da RAPA gudanarwa. Ana tsammanin matakan phosphate na plasma za a tsawaita fitar da phosphate daga cikin koda da aka dasa ta hanyar RAPA na tushen immunosuppressive far.Kamar sauran magungunan rigakafi, RAPA yana da damar samun damar kamuwa da cuta, tare da rahoton da aka ruwaito don ƙara yawan ciwon huhu musamman, amma faruwar wasu cututtuka masu dama ba su bambanta da CsA ba.
Tasirin Toxicological
Chondroitin sulfate yana wanzuwa sosai a cikin nama na guringuntsi na mutum da na dabba.Shirye-shiryen magani ya ƙunshi isomers biyu na chondroitin sulfate A da chondroitin sulfate C, kuma abun ciki na chondroitin sulfate a cikin guringuntsi na dabbobi daban-daban da shekaru daban-daban.Abubuwan da ke tattare da magunguna sune kamar haka: chondroitin sulfate na iya cire lipids da lipoproteins a cikin jini, cire cholesterol daga magudanar jini a kusa da zuciya, hanawa da magance atherosclerosis, da haɓaka yawan juzu'i na lipids da fatty acid a cikin sel.Chondroitin sulfate na iya hanawa da kuma bi da cututtukan zuciya yadda ya kamata.Yana da anti-atherosclerosis da anti-atherogenic plaque samuwar sakamako a kan gwaji arteriosclerosis model;yana ƙaruwa da rassan jijiyoyin jini ko wurare dabam dabam na atherosclerosis, kuma yana iya hanzarta gwaji na arteriosclerosis ko embolism.Waraka, sake farfadowa da kuma gyaran necrosis na myocardial ko lalata.Yana iya ƙara biosynthesis na cell messenger ribonucleic acid (mRNA) da deoxyribonucleic acid (DNA) kuma yana da tasiri na inganta metabolism cell.Ƙananan aikin maganin jijiyoyi.Chondroitin sulfate yana da matsakaicin sakamako na anticoagulant, kuma kowane 1 MG na chondroitin sulfate A daidai yake da aikin anticoagulant na 0.45U na heparin.Wannan aikin anticoagulant ba ya dogara da antithrombin III don taka rawarsa, yana iya yin aikin anticoagulant ta hanyar tsarin fibrinogen.Chondroitin sulfate kuma yana da anti-mai kumburi, saurin warkar da rauni da tasirin cutar kansa.
