Saukewa: CJC-1295

CJC-1295 API

Saukewa: CJC-1295wani roba ne, tetrastus peptide analogue naHormone mai sakin hormone girma (GHH), tsara donƙarfafawa da kuma ci gaba da ɓoyewar hormone girma na endogenous (GH). Ba kamar GHRH na asali ba, wanda ke da ɗan gajeren rabin rayuwa, CJC-1295 ya haɗa daFasahar Affinity Complex (DAC)., kyale shi ya ɗaure covalently zuwa albumin a cikin jini da kumatsawaita rabin rayuwar halittarta zuwa sama da kwanaki 8. Wannan sabon abu ya sa CJC-1295 aAnalog na GHRH mai tsayitare da tasiri mai mahimmanci a cikianti-tsufa, girma rashi, na rayuwa tsari, tsoka-ɓata cuta cuta, da kuma maganin farfadowa.

Tsarin Aiki

CJC-1295 yana aiki akanMai karɓa na GHRHwanda ke kan sel somatotropic a cikin glandan pituitary na gaba. Ayyukan nazarin halittu yana kwaikwayi na GHRH na asali, amma tare da tsawaita rabin rayuwa saboda gyare-gyaren DAC. Wannan ɗorewa mataki yana ba da damarbarga pulsatile saki na GHda kuma ƙara samar daInsulin-kamar girma factor 1 (IGF-1).

Manyan hanyoyin sun haɗa da:

• Ƙarfafawar ɓoyewar GH na endogenous

• Tsawon tsayin matakan IGF-1, goyon bayan tasirin anabolic

• Babu mahimmancin rashin jin daɗiko downregulation tare da ci gaba da amfani

• Ingantattun lipolysis, haɓakar furotin, da sabuntawar salula

Ta hanyar haifar da hanyoyin GH da IGF-1 na jiki, CJC-1295 yana nisantar da yawa daga cikin abubuwan da ke tattare da maganin GH na waje, kamar rashin jin daɗin mai karɓa da damuwa na aminci.

Binciken Farko da Ƙwararrun Ƙwararru

1. Rashin Girman Hormone (GHD)

A cikin gwaji na asibiti na farko, CJC-1295 ya nuna:

• Dorewa yana ƙaruwa cikinGHkumaFarashin IGF-1matakan har zuwa6-10 kwanakibayan allura daya

• Ragemitar alluraidan aka kwatanta da analogues na yau da kullun na GHRH ko alluran GH

• Ingantacciyar yarda da haƙuri da kwanciyar hankali na hormonal

2. Haɗin Jiki da Kiyaye tsoka

Nazarin dabba da ɗan adam sun nuna cewa CJC-1295:

• Yana haɓakadurƙusad da tsoka ribakumayana rage kitsen jiki, musamman mai visceral

• Yana haɓakawariƙewar nitrogen da haɗin furotina cikin skeletal tsoka

• Zai iya taimakawa a murmurewa dagasarcopeniada yanayin zubar da tsoka

3. Aikace-aikacen Anti-tsufa da Lafiya

Kamar yadda matakan GH da IGF-1 ke raguwa tare da shekaru, CJC-1295 yana ƙara karatu a matsayinanti-tsufa tsoma bakizuwa:

• Ingantaingancin barcikumatsarin rhythm circadian

• Haɓakaelasticity na fata, yawan kashi, kumaaikin rigakafi

• Taimakomakamashi metabolismkumajuriya gajiya

4. Tsarin Metabolic

CJC-1295 yana nuna alƙawarin yin maganainsulin juriyada Metabolism Syndrome ta hanyar:

• Ingantawaamfani da glucose

• Haɓakawalipid oxidationkumaadipose nama metabolism

• Taimakawasarrafa nauyia cikin masu kiba ko pre-ciwon sukari

API Kerawa da Kula da Inganci

At Gentolex Group, muCJC-1295 APIana yin amfani da shiTsarin peptide mai ƙarfi (SPPS)da tsarkakewa ta amfani da HPLC don cimma babban tsafta da daidaiton tsari-zuwa-tsari.

Maɓalli Maɓalli:

• Tsafta ≥ 99%(HPLC ta tabbatar)

• Low ragowar kaushi da nauyi karafa

• Endotoxin-free, mara-immunogenic hanyar kira

• Akwai a cikial'ada yawa: milligram zuwa kilogiram ma'auni

Aikace-aikace da Yiwuwar Gaba

Ana ɗaukar CJC-1295 ɗayan mafi kyawun kwatancen GHRH na dogon lokaci, tare da yuwuwar aikace-aikace a:

• Maganin raunin GH na manya

• Gudanar da tsarin jiki a cikin kiba da tsufa

• Gyarawa daga asarar tsoka ko rauni

• Ayyukan aiki da haɓakawa a cikin asibiti ko saitunan wasanni

• Maganin tallafi a cikin gajiya na yau da kullun, fibromyalgia, da rashin daidaituwa na neuroendocrine

Gwaje-gwaje na asibiti masu ci gaba suna bincika amfani da shi azaman madadinrecombinant GH, musamman a cikin neman yawan jama'amafi aminci, ƙarin daidaitawar hormone physiological.