Leuprorelin Acetate Yana Gudanar da Sigar Hormones na Gonadal
Cikakken Bayani
| Suna | Leuprorelin |
| Lambar CAS | 53714-56-0 |
| Tsarin kwayoyin halitta | Saukewa: C59H84N16O12 |
| Nauyin kwayoyin halitta | 1209.4 |
| Lambar EINECS | 633-395-9 |
| Takamaiman juyawa | D25 -31.7° (c = 1 a cikin 1% acetic acid) |
| Yawan yawa | 1.44± 0.1 g/cm3 (An annabta) |
| Yanayin ajiya | -15°C |
| Siffar | M |
| Yawan acidity | (pKa) 9.82 ± 0.15 (An annabta) |
| Ruwa mai narkewa | Mai narkewa a cikin ruwa a 1 MG / ml |
Makamantu
LH-RHLEUPROLIDE; LEUPROLIDE; LEUPROLIDE (DAN-Adamu); LEUPRORELIN; DES-GLY10,D-LEU6,PRO-NHET9) - LUTEINIZING HORMONE-SANARWAFACTOR;
Tasirin Pharmacological
Leuprolide, goserelin, triprelin, da nafarelin wasu magunguna ne da aka saba amfani da su a aikin asibiti don cire ovaries don maganin ciwon nono na premenopausal da ciwon prostate.(wanda ake magana da shi azaman GnRH-a kwayoyi), GnRH-magungunan suna kama da tsarin GnRH kuma suna gasa tare da masu karɓar GnRH na pituitary.Wato, gonadotropin da pituitary ke ɓoyewa yana raguwa, wanda ke haifar da raguwa mai yawa a cikin hormone na jima'i da kwai ya ɓoye.
Leuprolide analog ne na hormone mai sakin gonadotropin (GnRH), peptide wanda ya ƙunshi amino acid 9.Wannan samfurin zai iya hana aikin tsarin pituitary-gonadadal yadda ya kamata, juriya ga enzymes proteolytic da alaƙa da mai karɓa na GnRH pituitary sun fi GnRH ƙarfi, kuma ayyukan haɓaka sakin hormone luteinizing (LH) kusan sau 20 ne. da GnRH.Hakanan yana da tasirin hanawa mai ƙarfi akan aikin pituitary-gonad fiye da GnRH.A matakin farko na jiyya, follicle stimulating hormone (FSH), LH, estrogen ko androgen na iya ƙara dan lokaci, sa'an nan kuma, saboda rage responsiveness na pituitary gland shine yake hana mugunya na FSH, LH da estrogen ko androgen. yana haifar da dogaro ga hormones na jima'i.Cututtukan jima'i (kamar prostate cancer, endometriosis, da dai sauransu) suna da tasirin warkewa.
A halin yanzu, gishirin acetate na leuprolide ana amfani dashi a asibiti, saboda aikin leuprolide acetate ya fi karko a dakin da zafin jiki.Ya kamata a zubar da ruwa.Ana iya amfani dashi don maganin simintin magani na endometriosis da fibroids na mahaifa, tsakiyar precocious balaga, ciwon nono premenopausal da ciwon gurguwar prostate, da kuma zubar da jini na aikin mahaifa wanda aka hana ko rashin tasiri ga maganin hormone na al'ada.Hakanan za'a iya amfani da shi azaman premedication kafin cirewar endometrial, wanda zai iya yin bakin ciki daidai da endometrium, rage kumburi, da rage wahalar tiyata.
