Daptomycin 103060-53-3 don Cututtuka masu Yaduwa
Cikakken Bayani
| Suna | Daptomycin |
| Lambar CAS | 103060-53-3 |
| Tsarin kwayoyin halitta | Saukewa: C72H101N17O26 |
| Nauyin kwayoyin halitta | 1620.67 |
| Lambar EINECS | 600-389-2 |
| Wurin narkewa | 202-204 ° C |
| Wurin tafasa | 2078.2 ± 65.0 °C (An annabta) |
| Yawan yawa | 1.45± 0.1 g/cm3 (An annabta) |
| Wurin walƙiya | 87 ℃ |
| Yanayin ajiya | An rufe shi a bushe, Ajiye a cikin injin daskarewa, ƙasa da -20 ° C |
| Solubility | Methanol: mai narkewa 5mg/ml |
| Yawan acidity | (pKa) 4.00± 0.10 (An annabta) |
| Siffar | foda |
| Launi | mara launi zuwa suma rawaya |
Makamantu
N-[N- (1-Oxodecyl) -L-Trp-D-Asn-L-Asp-] -cyclo[L-Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R) -3-methyl-L-Glu-] -4- (2-aminophen-l) -4-bu ;N-[N-Decanoyl-L-Trp-D-Asn-L-Asp-] -cyclo[Thr*-Gly-L-Orn-L-Asp-D-Ala-L-Asp-Gly-D-Ser-[(3R) -3-methyl-L-Glu-]-3- (2-aminobenzoyl)-]- (2-aminobenzoyl) -L-Ala- (1-) (1-Ala) ecyl -L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithinyl-L-a-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R)-3-methyl-L-a- glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;DAPTOMYCINE;Dapcin;Daptomycin,>=99%;DaptomycinReadyMadeSolution;Daptomycin(LY146032)
Bayani
Kwayoyin daptomycin kwayoyin cuta ne na lipopeptide na cyclic tare da sabon tsarin da aka samo daga fermentation broth na Streptomyces (S. reseosporus), wanda ke hana biosynthesis na peptidoglycan cell cell ta hanyar damun jigilar amino acid a cikin tantanin halitta. Canza kaddarorin membrane na cytoplasmic na iya rushe aikin membrane na kwayan cuta ta hanyoyi da yawa kuma yana kashe kwayoyin cutar Gram da sauri. Bugu da ƙari, ikonsa na yin aiki a kan mafi yawan kwayoyin cutar Gram-positive, daptomycin ya fi muhimmanci ga keɓaɓɓen nau'ikan da suka nuna juriya ga methicillin, vancomycin, da linezolid a cikin vitro. Yana da aiki mai ƙarfi, kuma wannan kadarar tana da mahimmancin tasiri na asibiti ga marasa lafiya masu fama da cutar. Eosinophilic pneumonia cuta ce da ba kasafai ba kuma mai tsananin gaske tare da alamun zazzabi, tari, ƙarancin numfashi, da wahalar numfashi.
Tasirin Kwayoyin cuta
Daptomycin yana da kyakkyawan aiki na bacteriostatic akan ƙwayoyin ƙwayoyin cuta daban-daban, irin su MIC=0.06-0.5 μg/ml don methicillin-resistant Staphylococcus aureus (MRSA), da Staphylococcus aureus (MRSA) mai jurewa methicillin. MIC = 0.0625 ~ 1μg / ml don kwayoyin cuta, MIC = 0.12～0.5μg / ml don Staphylococcus epidermidis-resistant oxacillin, MIC = 2.5μg / ml don enterococcus mai jure wa maganin rigakafi na aminoglycoside, MIC = 2.5μg / ml don Gmrcoccus - The MIC 0.5 ~ 1 μg / ml, da MIC na Enterococcus resistant zuwa glycopeptide maganin rigakafi ne 1 ~ 2μg / ml.
