GH / IGF-1 yana rage physiologically tare da shekaru, kuma waɗannan canje-canjen suna tare da gajiya, atrophy na tsoka, ƙara yawan ƙwayar adipose, da kuma rashin fahimta a cikin tsofaffi ...
A cikin 1990, Rudman ya buga takarda a cikin New England Journal of Medicine wanda ya gigice al'ummar likitocin - "Amfani da Hormone na Ci gaban Dan Adam a cikin Mutane Sama da Shekaru 60". Rudman ya zaɓi maza 12 masu shekaru 61-81 don gwaji na asibiti:
Bayan watanni 6 na allurar hGH, batutuwa suna da matsakaicin karuwa na 8.8% a cikin ƙwayar tsoka, 14.4% a cikin asarar mai, 7.11% a cikin fata fata, 1.6% a cikin girman kashi, 19% a cikin hanta da 17% a cikin splin idan aka kwatanta da ƙungiyar kula da sauran tsofaffi na zamani. %, an kammala cewa canje-canje na tarihi a cikin duk batutuwa sun kasance 10 zuwa 20 shekaru matasa.
Wannan ƙarshe ya haifar da haɓaka haɓakar haɓakar haɓakar haɓakar ɗan adam (rhGH) azaman maganin rigakafin tsufa, kuma shine tushen tushen imanin mutane da yawa cewa allurar rhGH na iya hana tsufa. Tun daga wannan lokacin, yawancin likitocin sun yi amfani da hGH azaman maganin tsufa, kodayake FDA ba ta yarda da su ba.
Duk da haka, yayin da bincike ya ci gaba da zurfafawa, masana kimiyya sun gano cewa ƙananan amfani ga jiki na haɓaka aikin GH / IGF-1 axis ba ya tsawanta rayuwar tsofaffi, amma a maimakon haka yana haifar da haɗari ga lafiya:
Mice oversecreting GH suna da girma, amma suna da 30% -40% guntu tsawon rayuwa fiye da nau'in berayen daji [2], da canje-canje na tarihi (glomerulosclerosis da haɓakar hanta) suna faruwa a cikin mice tare da matakan GH masu girma. babba) da juriya na insulin.
Babban matakan GH yana haɓaka haɓakar tsokoki, ƙasusuwa, da gabobin ciki, wanda ke haifar da gigantism (a cikin yara) da acromegaly (a cikin manya). Manya da wuce haddi GH ana danganta su da ciwon sukari da matsalolin zuciya, da kuma haɗarin ciwon daji mafi girma.
Lokacin aikawa: Jul-22-2022