Magungunan Magunguna
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Fmoc-Lys(Pal-Glu-OtBu) -OH
Fmoc-Lys(Pal-Glu-OtBu) -OH ƙwararren ginin amino acid ne na lipid wanda aka tsara don haɗuwa da peptide-lipid. Yana da fasalin lysine mai kariya ta Fmoc tare da sarkar gefen palmitoyl-glutamate, yana haɓaka alaƙar membrane da bioavailability.
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Fmoc-His-Aib-OH
Fmoc-His-Aib-OH shine toshe ginin dipeptide da aka yi amfani da shi a cikin kirar peptide, yana haɗa Fmoc-protected histidine da Aib (α-aminoisobutyric acid). Aib yana gabatar da rigidity mai daidaituwa, yana mai da shi mahimmanci don ƙirƙira helical da tsayayyen peptides.
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Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
Boc-His (Trt) -Aib-Glu (OtBu) - Gly-OH wani yanki ne na tetrapeptide mai kariya wanda aka yi amfani dashi a cikin haɗin peptide da ci gaban ƙwayoyi. Ya ƙunshi ƙungiyoyin ayyuka masu kariya da dabaru don haɗin kai na mataki-mataki da fasali Aib (α-aminoisobutyric acid) don haɓaka kwanciyar hankali na helix da rigidity mai daidaitawa.
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Ste-γ-Glu-AEEA-AEEA-OSU
Ste-γ-Glu-AEEA-AEEA-OSU sinadari ne na roba mai haɗaɗɗiyar ƙwayar cuta wanda aka ƙera don isar da magunguna da aka yi niyya da haɗin gwiwar magungunan-magungunan (ADCs). Yana fasalta wutsiya ta stearoyl (Ste) hydrophobic, γ-glutamyl manufa motif, AEEA spacers don sassauci, da ƙungiyar OSu (NHS ester) don ingantaccen haɗin gwiwa.
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Fmoc-Ile-αMeLeu-Leu-OH
Fmoc-Ile-αMeLeu-Leu-OH wani shingen gini ne na roba mai kariya na tripeptide wanda ke nuna α-methylated leucine, wanda aka saba amfani dashi a ƙirar magungunan peptide don haɓaka kwanciyar hankali na rayuwa da zaɓin mai karɓa.
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Dodecyl Phosphocholine (DPC)
Dodecyl Phosphocholine (DPC) wani wanki ne na roba na roba wanda aka yi amfani dashi sosai a cikin binciken furotin na membrane da tsarin tsarin halitta, musamman a cikin NMR spectroscopy da crystallography.
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Donidalorsen
Donidalorsen API wani maganin antisense oligonucleotide (ASO) ne a ƙarƙashin bincike don maganin angioedema na gado (HAE) da kuma yanayin kumburi masu alaƙa. Ana nazarin shi a cikin mahallin hanyoyin kwantar da hankali na RNA, da nufin rage bayyanar cututtukaplasma prekallikrein(KLKB1 mRNA). Masu bincike suna amfani da Donidalorsen don bincika hanyoyin yin shiru na kwayoyin halitta, magunguna masu dogara da kashi, da kuma kulawa na dogon lokaci na kumburi mai shiga tsakani na bradykinin.
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Fitusiran
Fitusiran API wani ƙaramin RNA ne mai tsoma baki (siRNA) wanda aka bincika da farko a fagen cutar haemophilia da rikicewar coagulation. Yana kaiwa hariAntithrombin (AT ko SERPINC1)kwayoyin halitta a cikin hanta don rage samar da antithrombin. Masu bincike suna amfani da Fitusiran don bincika hanyoyin tsangwama na RNA (RNAi), takamaiman ƙwayoyin halittar hanta, da sabbin dabarun warkewa don sake daidaita coagulation a cikin marasa lafiya na hemophilia A da B, tare da ko ba tare da masu hanawa ba.
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Givosiran
Givosiran API wani ƙaramin RNA ne mai shiga tsakani (siRNA) wanda aka yi nazari don maganin cututtukan hanta mai tsanani (AHP). Yana musamman hari daALAS1gene (aminolevulinic acid synthase 1), wanda ke da hannu a cikin hanyar heme biosynthesis. Masu bincike suna amfani da Givosiran don yin bincike kan tsoma bakin RNA (RNAi), hanyoyin kwantar da hankali na hanta da ke da niyya, da daidaita hanyoyin hanyoyin rayuwa da ke cikin porphyria da cututtukan ƙwayoyin cuta masu alaƙa.
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Plozasiran
Plozasiran API shine ƙaramin RNA (siRNA) na roba wanda aka haɓaka don maganin hypertriglyceridemia da cututtukan zuciya da jijiyoyin jini da ke da alaƙa. Yana kaiwa hariAPOC3Halitta, wanda ke ɓoye apolipoprotein C-III, mai mahimmanci mai kula da metabolism na triglyceride. A cikin bincike, ana amfani da Plozasiran don yin nazarin dabarun rage yawan lipid na tushen RNAi, ƙayyadaddun ƙayyadaddun kwayoyin halitta, da kuma dogon aiki na jiyya don yanayi irin su cututtukan chylomicronemia na iyali (FCS) da gauraye dyslipidemia.
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Zilebesiran
Zilebesiran API ƙaramin bincike ne na RNA (siRNA) wanda aka haɓaka don maganin hauhawar jini. Yana kaiwa hariAGTgene, wanda ke ɓoye angiotensinogen-wani maɓalli mai mahimmanci na tsarin renin-angiotensin-aldosterone (RAAS). A cikin bincike, ana amfani da Zilebesiran don nazarin hanyoyin yin shiru na kwayoyin halitta don sarrafa hawan jini na dogon lokaci, fasahar isar da RNAi, da kuma faffadan rawar hanyar RAAS a cikin cututtukan zuciya da na koda.
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Caspofungin don kamuwa da cututtukan fungal
Suna: Caspofungin
Lambar CAS: 162808-62-0
Tsarin kwayoyin halitta: C52H88N10O15
Nauyin Kwayoyin: 1093.31
Lambar EINECS: 1806241-263-5
Matsayin tafasa: 1408.1 ± 65.0 °C (An annabta)
Yawan yawa: 1.36± 0.1 g/cm3(an annabta)
Adadin acidity: (pKa) 9.86± 0.26 (an annabta)