Atosiban Acetate da ake amfani da shi don Haihuwar Haihuwa
Cikakken Bayani
| Suna | Atosiban |
| Lambar CAS | 90779-69-4 |
| Tsarin kwayoyin halitta | Saukewa: C43H67N11O12S2 |
| Nauyin kwayoyin halitta | 994.19 |
| Lambar EINECS | 806-815-5 |
| Wurin tafasa | 1469.0 ± 65.0 °C (An annabta) |
| Yawan yawa | 1.254± 0.06 g/cm3 (An annabta) |
| Yanayin ajiya | -20°C |
| Solubility | H2O: ≤100 mg/ml |
Bayani
Atosiban acetate shine polypeptide cyclic cyclic disulfide wanda ya ƙunshi amino acid 9. Yana da kwayoyin oxytocin da aka gyara a matsayi 1, 2, 4 da 8. N-terminus na peptide shine 3-mercaptopropionic acid (thiol da rukunin sulfhydryl na [Cys] 6 suna samar da haɗin disulfide), C-terminal yana cikin nau'i na amide, amino acid na biyu da aka gyara shine N-terminal modified. [D-Tyr (Et)] 2, kuma ana amfani da atosiban acetate a cikin magunguna kamar vinegar Yana wanzu a cikin nau'in gishiri na acid, wanda aka fi sani da atosiban acetate.
Aikace-aikace
Atosiban shine oxytocin da vasopressin V1A hade da antagonist mai karɓa, mai karɓa na oxytocin yana da tsarin kama da mai karɓa na vasopressin V1A. Lokacin da aka toshe mai karɓar oxytocin, oxytocin zai iya yin aiki ta hanyar mai karɓa na V1A, don haka ya zama dole a toshe hanyoyin masu karɓa guda biyu na sama a lokaci guda, kuma gaba ɗaya na mai karɓa ɗaya zai iya hana ƙwayar mahaifa ta yadda ya kamata. Wannan kuma shine ɗayan manyan dalilan da ya sa agonists β-receptor, masu hana tashar calcium da masu hana prostaglandin synthase ba za su iya hana haɓakar mahaifa ba yadda ya kamata.
Tasiri
Atosiban shine haɗe-haɗe antagonist na oxytocin da vasopressin V1A, tsarin sinadaransa yayi kama da biyun, kuma yana da alaƙa mai girma ga masu karɓa, kuma yana gasa tare da oxytocin da vasopressin V1A receptors, ta haka ne ya toshe hanyar aiki na oxytocin da vasopressin da kuma rage karfin mahaifa.
