Linaclotide don Ciwon Gastrointestinal 851199-59-2
Cikakken Bayani
| Suna | Linaclotide |
| Lambar CAS | 851199-59-2 |
| Tsarin kwayoyin halitta | Saukewa: C59H79N15O21S6 |
| Nauyin kwayoyin halitta | 1526.74 |
Makamantu
linaclotide -L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-,cyclic(1→6),(2→10),(5→13) -tris (disulfide)
Bayani
Linaclotide, wani tsari na peptide na roba wanda ya ƙunshi amino acid 14, yana da alaƙa da dangin guanosine peptide na endogenous kuma shine kawai FDA-an yarda da GC-C (guanylate) Cyclase-C) magungunan agonist don maganin ciwon hanji mai banƙyama tare da maƙarƙashiya (IBS-C) da maƙarƙashiya na yau da kullun a cikin manya (Cyclase-C).
Abubuwan Sinadarai
Linaclotide fari ne zuwa fari-fari amorphous foda; dan kadan mai narkewa a cikin ruwa da maganin sodium chloride mai ruwa (0.9%).
Yadda yake aiki
Linaclotide shine guanylate cyclase-C agonist mai karɓa (GCCA) tare da aikin analgesic na visceral da ayyukan endocrine. Dukansu linaclotide da metabolite mai aiki suna iya ɗaure ga mai karɓar guanylate cyclase-C (GC-C) akan saman haske na ƙananan epithelium na hanji. A cikin nau'ikan dabbobi, linaclotide yana rage ciwon visceral kuma yana haɓaka jigilar gastrointestinal ta hanyar kunna GC-C, kuma a cikin mutane, miyagun ƙwayoyi kuma yana ƙara haɓakar ƙwayar cuta. Sakamakon kunnawa GC-C yana ƙaruwa da yawa na ciki da kuma extracellular cGMP (cyclic guanosine monophosphate). Extracellular cGMP na iya rage ayyukan zaruruwan jijiyoyi masu zafi da rage ciwon visceral a cikin dabbobin samfuri. Intracellular cGMP na iya ƙara fitowar chloride da bicarbonate a cikin ƙananan hanji ta hanyar kunna CFTR (cystic fibrosis transmembrane conductance regulator), wanda a ƙarshe yana haifar da haɓakar ƙananan ƙwayar hanji da sauri na ƙananan hanji.
FAQ
Kuna ba da garantin isar da samfuran lafiya da aminci?
Ee, koyaushe muna amfani da fakitin fitarwa mai inganci koyaushe. Har ila yau, muna amfani da ƙwaƙƙwaran haɗaɗɗiyar haɗari don kaya masu haɗari da ingantattun masu jigilar sanyi don abubuwa masu zafin zafi. Marufi na ƙwararru da buƙatun buƙatun da ba daidai ba na iya haifar da ƙarin caji.
Yaya game da kuɗin jigilar kaya?
Farashin jigilar kaya ya dogara da hanyar da kuka zaɓi don samun kayan. Express yawanci hanya ce mafi sauri amma kuma mafi tsada. Ta hanyar jigilar ruwa shine mafi kyawun mafita ga adadi mai yawa. Daidai farashin kaya za mu iya ba ku kawai idan mun san cikakkun bayanai na adadin, nauyi da hanya. Da fatan za a tuntuɓe mu don ƙarin bayani.
