Suna | N- (n-glycylglycyl) glycyl) -8-l-lysinepressin |
Lambar CAS | 14636-12-5 |
Tsarin kwayoyin halitta | C52H74N16O15s2 |
Nauyi na kwayoyin | 1227.37 |
Lambar Einecs | 238-680-8 |
Tafasa | 1824.0 ± 65.0 ° C (annabta) |
Yawa | 1.46 ± 0.1 g / cm3 (annabta) |
Yanayin ajiya | Rike cikin wuri mai duhu, yanayin Inert, Store a cikin injin daskarewa, a ƙarƙashin -15 ° C. |
Acidarancin acid | (Pka) 9.90 ± 0.15 (annabta) |
[N-α-triglyl-8-Lysine] -veoprestin; 130: PN: WO2010032207SEPROPTOIN; 1-triglyc-8-Lysineprestin; Nα-glycyl-glycyl-glycyl- [8-Lysine] -veoprestin; Nα-glycyl-glycyl-glycyl-lynine-vasopresin; Nα-glycylglycylglycyl-vasopresin; Nα-gly-gly-8-Lys-vasopresin; Terlipritsin, Terlipressine, Terlipressine, Terlipritirsinum.
Terlipressin, wanda sunadarai sunan shine triglylysine vasopressin, shine sabon shiri na roba mai ɗorewa. Wata irin prodrug, wanda ba shi da aiki da kanta. An yi amfani da amaropptidoDase a Vivo don sannu a hankali "saki" Lysine mai aiki Vasepressin bayan cire ragowar glycressin guda uku a cikin N-Ternyl. Saboda haka, Terlipresin yana aiki a matsayin tafki wanda ya saki Lynoopressin vasein a wani mawuyacin kudi.
A sakamakon magunguna na terlipresin shine kwangila splolanchic vascular m tsoka da rage jini kwarara da matsi da kai da matsi da kai. A gefe guda, hakanan zai iya rage plasma sakamakon tasirin Renin taro, ta yadda ya karu kwararar jini da haɓaka aikin fitsari a cikin marasa lafiya tare da cututtukan hepatorenal. Terlipressin a halin yanzu kawai magani ne kawai wanda zai iya inganta maganin rayuwa na marasa lafiya tare da vesophageal mustat basur. An yi amfani da shi a mafi yawan lura na asibiti na basur. Bugu da kari, an kuma yi amfani da terlipressin da nasara a hanta da koda. Gabaɗaya, yana iya yin takaicin rawar da ake amfani da shi a cikin maimaitawar rawar jiki da kuma sake farfadowa. Idan aka kwatanta da Vasopressin, yana da sakamako mai dorewa, baya haifar da rikice-rikice masu haɗari, ciki har da manyan abubuwa a cikin tsarin zuciya, kuma yana da sauki a yi amfani da (allurar ciki), wanda ya fi dacewa da m kulawa da m kulawa. Ceta da magani na marasa lafiya marasa lafiya.