Terlipressin Acetate na Esophageal Variceal Bleeding
Cikakken Bayani
| Suna | N (N- (N-Glycylglycyl) glycyl) -8-L-lysinevasopressin |
| Lambar CAS | 14636-12-5 |
| Tsarin kwayoyin halitta | Saukewa: C52H74N16O15S2 |
| Nauyin kwayoyin halitta | 1227.37 |
| Lambar EINECS | 238-680-8 |
| Wurin tafasa | 1824.0 ± 65.0 °C (An annabta) |
| Yawan yawa | 1.46± 0.1 g/cm3 (An annabta) |
| Yanayin ajiya | Ajiye a wuri mai duhu, yanayi mara kyau, Ajiye a cikin injin daskarewa, ƙasa da -15 ° C. |
| Yawan acidity | (pKa) 9.90± 0.15 (An annabta) |
Makamantu
[N-α-Triglycyl-8-lysine] -vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine] -vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, terlipressin, terlipressin, terlipressin, terlipressin.
Bayani
Terlipressin, wanda sunansa sunansa shine triglycyllysine vasopressin, sabon shiri ne na vasopressin na roba. Wani nau'in prodrug ne, wanda baya aiki da kansa. Aminopeptidase ne ke yin shi a cikin vivo don a hankali "saki" lysine vasopressin mai aiki bayan cire ragowar glycyl guda uku a N-terminus. Saboda haka, terlipressin yana aiki a matsayin tafki wanda ke sakin lysine vasopressin a daidai lokacin.
Sakamakon pharmacological na terlipressin shine ƙaddamar da ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (kamar rage yawan jini a cikin mesentery, splin, mahaifa, da dai sauransu). A gefe guda kuma, yana iya rage ƙwayar plasma Tasirin maida hankali na renin, don haka ƙara yawan jini na koda, inganta aikin koda da ƙara yawan fitsari a cikin marasa lafiya da ciwon hanta. Terlipressin a halin yanzu shine kawai magani wanda zai iya inganta yawan rayuwa na marasa lafiya tare da zubar da jini na esophageal variceal. An yi amfani da shi musamman wajen maganin ciwon jini na variceal. Bugu da ƙari, an yi amfani da terlipressin cikin nasara a cikin hanta da koda. Gabaɗaya, yana yiwuwa ya taka rawa mai fa'ida a cikin haɗuwa tare da girgiza damuwa da farfaɗowar zuciya. Idan aka kwatanta da vasopressin, yana da tasiri mai dorewa, baya haifar da rikitarwa masu haɗari, ciki har da fibrinolysis da rikitarwa mai tsanani a cikin tsarin zuciya da jijiyoyin jini, kuma yana da sauƙin amfani (alurar rigakafi), wanda ya fi dacewa da kulawa mai mahimmanci da mahimmanci. Ceto da kula da marasa lafiya marasa lafiya.
